8AS0
PD-1 extracellular domain in complex with Fab fragment from D12 antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J, M... (C, D, G, J, M...) | D12 antibody light chain, Fab fragment | polymer | 214 | 23343.9 | 8 | Homo sapiens | ||
| 2 | B, E, H, K, N... (B, E, H, K, N...) | D12 antibody heavy chain, Fab fragment | polymer | 225 | 23792.6 | 8 | Homo sapiens | ||
| 3 | C, F, I, L, O... (A, F, I, L, O...) | Programmed cell death protein 1 | polymer | 168 | 19073.2 | 8 | UniProt (Q15116) Pfam (PF07686) | Homo sapiens (human) | Protein PD-1,hPD-1 |
| 4 | Y (U) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | GA, HA, KA, Z (g, h, k, Z) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 4 | In PDB GlyTouCan (G32152BH) | |||
| 6 | AA, EA, JA (a, e, j) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 7 | BA (b) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 8 | CA (c) | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G27425HP) | |||
| 9 | DA, IA (d, i) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 10 | FA (f) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB | |||
| 11 | LA, MA, NA, OA, PA... (F, I, L, O, R...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
A, F, I, L, O, R, X, Y: 24 - 170 (UniProt: Q15116)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Leu 172 | - | expression tag |
| Asn 173 | - | expression tag |
| Asp 174 | - | expression tag |
| Ile 175 | - | expression tag |
| Phe 176 | - | expression tag |
| Glu 177 | - | expression tag |
| Ala 178 | - | expression tag |
| Gln 179 | - | expression tag |
| Lys 180 | - | expression tag |
| Ile 181 | - | expression tag |
| Glu 182 | - | expression tag |
| Trp 183 | - | expression tag |
| His 184 | - | expression tag |
| Glu 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 529677.3 | |
| Branched | Number of molecules | 13 |
| Total formula weight | 8339.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 539786.7 |
