5MC6
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![BU of 5mc6 by Molmil](/molmil-images/mine/5mc6) | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | Deposit date: | 2016-11-09 | Release date: | 2017-01-18 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Science, 354, 2016
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4V8M
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![BU of 4v8m by Molmil](/molmil-images/mine/4v8m) | High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome | Descriptor: | 18S RRNA OF THE SMALL RIBOSOMAL SUBUNIT, 40S RIBOSOMAL PROTEIN S10, PUTATIVE, ... | Authors: | Hashem, Y, des Georges, A, Fu, J, Buss, S.N, Jossinet, F, Jobe, A, Zhang, Q, Liao, H.Y, Grassucci, R.A, Bajaj, C, Westhof, E, Madison-Antenucci, S, Frank, J. | Deposit date: | 2012-12-09 | Release date: | 2014-07-09 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.57 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome. Nature, 494, 2013
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5MEI
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![BU of 5mei by Molmil](/molmil-images/mine/5mei) | Crystal structure of Agelastatin A bound to the 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O. | Deposit date: | 2016-11-15 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol, 24, 2017
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6J6G
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![BU of 6j6g by Molmil](/molmil-images/mine/6j6g) | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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1U2V
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![BU of 1u2v by Molmil](/molmil-images/mine/1u2v) | Crystal structure of Arp2/3 complex with bound ADP and calcium | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-Related Protein 2, Actin-Related Protein 3, ... | Authors: | Nolen, B.J, Littlefield, R.S, Pollard, T.D. | Deposit date: | 2004-07-20 | Release date: | 2004-11-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP Proc.Natl.Acad.Sci.Usa, 101, 2004
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5MQF
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![BU of 5mqf by Molmil](/molmil-images/mine/5mqf) | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX8, Cell division cycle 5-like protein, ... | Authors: | Bertram, K, Hartmuth, K, Kastner, B. | Deposit date: | 2016-12-20 | Release date: | 2017-03-22 | Last modified: | 2018-11-21 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature, 542, 2017
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4V6X
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![BU of 4v6x by Molmil](/molmil-images/mine/4v6x) | Structure of the human 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | Deposit date: | 2013-02-27 | Release date: | 2014-07-09 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
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4V8Y
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![BU of 4v8y by Molmil](/molmil-images/mine/4v8y) | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | Deposit date: | 2013-07-20 | Release date: | 2014-07-09 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular architecture of a eukaryotic translational initiation complex. Science, 342, 2013
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1TYQ
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![BU of 1tyq by Molmil](/molmil-images/mine/1tyq) | Crystal structure of Arp2/3 complex with bound ATP and calcium | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related Protein 2, Actin-related protein 3, ... | Authors: | Nolen, B.J, Littlefield, R.S, Pollard, T.D. | Deposit date: | 2004-07-08 | Release date: | 2004-11-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP Proc.Natl.Acad.Sci.Usa, 101, 2004
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6J6H
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![BU of 6j6h by Molmil](/molmil-images/mine/6j6h) | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J6N
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![BU of 6j6n by Molmil](/molmil-images/mine/6j6n) | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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5FCJ
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![BU of 5fcj by Molmil](/molmil-images/mine/5fcj) | Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. | Deposit date: | 2015-12-15 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
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5FLX
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![BU of 5flx by Molmil](/molmil-images/mine/5flx) | Mammalian 40S HCV-IRES complex | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | Authors: | Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. | Deposit date: | 2015-10-28 | Release date: | 2015-12-23 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA. Embo J., 34, 2015
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5UKM
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![BU of 5ukm by Molmil](/molmil-images/mine/5ukm) | bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as) | Descriptor: | 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cruz-Rodriguez, O, Tesmer, J.J.G. | Deposit date: | 2017-01-23 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60, 2017
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2BCJ
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![BU of 2bcj by Molmil](/molmil-images/mine/2bcj) | |
6SV4
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![BU of 6sv4 by Molmil](/molmil-images/mine/6sv4) | The cryo-EM structure of SDD1-stalled collided trisome. | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R. | Deposit date: | 2019-09-17 | Release date: | 2020-03-04 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat.Struct.Mol.Biol., 27, 2020
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6SNT
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![BU of 6snt by Molmil](/molmil-images/mine/6snt) | Yeast 80S ribosome stalled on SDD1 mRNA. | Descriptor: | 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S10-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R. | Deposit date: | 2019-08-27 | Release date: | 2020-03-04 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat.Struct.Mol.Biol., 27, 2020
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6T7I
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![BU of 6t7i by Molmil](/molmil-images/mine/6t7i) | Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination. | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R. | Deposit date: | 2019-10-22 | Release date: | 2019-12-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts. Embo J., 39, 2020
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6T4Q
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![BU of 6t4q by Molmil](/molmil-images/mine/6t4q) | Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination. | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R. | Deposit date: | 2019-10-14 | Release date: | 2019-12-25 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts. Embo J., 39, 2020
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6TB4
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![BU of 6tb4 by Molmil](/molmil-images/mine/6tb4) | Structure of SAGA bound to TBP | Descriptor: | SAGA-associated factor 73 (Sgf73), Spt20, Subunit (17 kDa) of TFIID and SAGA complexes, ... | Authors: | Papai, G, Frechard, A, Kolesnikova, O, Crucifix, C, Schultz, P, Ben-Shem, A. | Deposit date: | 2019-10-31 | Release date: | 2020-01-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of SAGA and mechanism of TBP deposition on gene promoters. Nature, 577, 2020
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1OMW
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![BU of 1omw by Molmil](/molmil-images/mine/1omw) | Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits | Descriptor: | G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 | Authors: | Lodowski, D.T, Pitcher, J.A, Capel, W.D, Lefkowitz, R.J, Tesmer, J.J.G. | Deposit date: | 2003-02-26 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma Science, 300, 2003
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7OHQ
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![BU of 7ohq by Molmil](/molmil-images/mine/7ohq) | |
7OHS
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![BU of 7ohs by Molmil](/molmil-images/mine/7ohs) | |
7OH3
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![BU of 7oh3 by Molmil](/molmil-images/mine/7oh3) | |
7OHW
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![BU of 7ohw by Molmil](/molmil-images/mine/7ohw) | |