7XP5

Cryo-EM structure of a class T GPCR in ligand-free state

Summary for 7XP5

• Entry DOI: 10.2210/pdb7xp5/pdb
• EMDB information: 33365
• Descriptor: Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(t) subunit alpha-3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, taste type 2 receptors, cryo-electron microscopy structure, membrane protein
• Biological source: Acetivibrio thermocellus (Hungateiclostridium thermocellum); More
• Total number of polymer chains: 5
• Total formula weight: 184561.11

Authors

Liu, Z.J.,Hua, T.,Xu, W.X.,Wu, L.J. (deposition date: 2022-05-03, release date: 2022-10-12)

• Primary citation: Xu, W.,Wu, L.,Liu, S.,Liu, X.,Cao, X.,Zhou, C.,Zhang, J.,Fu, Y.,Guo, Y.,Wu, Y.,Tan, Q.,Wang, L.,Liu, J.,Jiang, L.,Fan, Z.,Pei, Y.,Yu, J.,Cheng, J.,Zhao, S.,Hao, X.,Liu, Z.J.,Hua, T.; Structural basis for strychnine activation of human bitter taste receptor TAS2R46.; Science, 377:1298-1304, 2022; PubMed: 36108005; DOI: 10.1126/science.abo1633

Experimental method

ELECTRON MICROSCOPY (3.08 Å)