1ZG4
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![BU of 1zg4 by Molmil](/molmil-images/mine/1zg4) | TEM1 beta lactamase | Descriptor: | Beta-lactamase TEM | Authors: | Stec, B, Holtz, K.M, Wojciechowski, C.L, Kantrowitz, E.R. | Deposit date: | 2005-04-20 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure of the wild-type TEM-1 beta-lactamase at 1.55 A and the mutant enzyme Ser70Ala at 2.1 A suggest the mode of noncovalent catalysis for the mutant enzyme. Acta Crystallogr.,Sect.D, 61, 2005
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1YT4
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![BU of 1yt4 by Molmil](/molmil-images/mine/1yt4) | Crystal structure of TEM-76 beta-lactamase at 1.4 Angstrom resolution | Descriptor: | Beta-lactamase TEM | Authors: | Thomas, V.L, Golemi-Kotra, D, Kim, C, Vakulenko, S.B, Mobashery, S, Shoichet, B.K. | Deposit date: | 2005-02-09 | Release date: | 2005-07-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM beta-Lactamase. Biochemistry, 44, 2005
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1ZG6
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![BU of 1zg6 by Molmil](/molmil-images/mine/1zg6) | TEM1 beta lactamase mutant S70G | Descriptor: | Beta-lactamase TEM | Authors: | Stec, B, Holtz, K.M, Wojciechowski, C.L, Kantrowitz, E.R. | Deposit date: | 2005-04-20 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the wild-type TEM-1 beta-lactamase at 1.55 A and the mutant enzyme Ser70Ala at 2.1 A suggest the mode of noncovalent catalysis for the mutant enzyme. Acta Crystallogr.,Sect.D, 61, 2005
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7TB7
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![BU of 7tb7 by Molmil](/molmil-images/mine/7tb7) | Crystal structure of D179N KPC-2 beta-lactamase | Descriptor: | CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | van den Akker, F, Alsenani, T. | Deposit date: | 2021-12-21 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TBX
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![BU of 7tbx by Molmil](/molmil-images/mine/7tbx) | Crystal structure of D179Y KPC-2 beta-lactamase | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | van den Akker, F, Alsenani, T. | Deposit date: | 2021-12-22 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TC1
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![BU of 7tc1 by Molmil](/molmil-images/mine/7tc1) | |
7U6Q
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![BU of 7u6q by Molmil](/molmil-images/mine/7u6q) | TEM-1 beta-lactamase | Descriptor: | Beta-lactamase, SULFATE ION | Authors: | Ji, Z, Boxer, S.G, Mathews, I.I. | Deposit date: | 2022-03-04 | Release date: | 2022-09-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases. J.Am.Chem.Soc., 144, 2022
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7TPU
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![BU of 7tpu by Molmil](/molmil-images/mine/7tpu) | Crystal structure of a chitinase-modifying protein from Fusarium vanettenii (Fvan-cmp) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-lactamase domain-containing protein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Dowling, N.V, Naumann, T.A, Price, N.P.J, Rose, D.R. | Deposit date: | 2022-01-26 | Release date: | 2023-02-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Crystal structure of a polyglycine hydrolase determined using a RoseTTAFold model. Acta Crystallogr D Struct Biol, 79, 2023
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7U9B
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![BU of 7u9b by Molmil](/molmil-images/mine/7u9b) | Crystal structure of indoline 7 with KPC-2 | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, [(3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-indol-1-yl][3-(trifluoromethyl)phenyl]methanone | Authors: | Akhtar, A, Chen, Y. | Deposit date: | 2022-03-10 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors To Be Published
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7UA7
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![BU of 7ua7 by Molmil](/molmil-images/mine/7ua7) | Crystal structure of indoline 9 with KPC-2 | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, tert-butyl {(3R)-3-[(1H-tetrazol-5-yl)carbamoyl]-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indol-3-yl}carbamate | Authors: | Akhtar, A, Chen, Y. | Deposit date: | 2022-03-11 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.247 Å) | Cite: | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors To Be Published
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7U8S
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![BU of 7u8s by Molmil](/molmil-images/mine/7u8s) | Crystal Structure of KPC-2 with compound 2 | Descriptor: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Carbapenem-hydrolyzing beta-lactamase KPC | Authors: | Akhtar, A, Chen, Y. | Deposit date: | 2022-03-09 | Release date: | 2023-03-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors To Be Published
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7U70
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![BU of 7u70 by Molmil](/molmil-images/mine/7u70) | Crystal Structure of CTX-M-14 with compound 2 | Descriptor: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Beta-lactamase | Authors: | Akhtar, A, Chen, Y. | Deposit date: | 2022-03-07 | Release date: | 2023-03-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors To Be Published
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7UTB
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![BU of 7utb by Molmil](/molmil-images/mine/7utb) | KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076 | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron | Authors: | van den Akker, F, Alsenani, T.A. | Deposit date: | 2022-04-26 | Release date: | 2022-12-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses. Antimicrob.Agents Chemother., 67, 2023
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7UON
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![BU of 7uon by Molmil](/molmil-images/mine/7uon) | CTX-M-14 Y105W mutant | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Judge, A, Hu, L, Sankaran, B, Van Riper, J, Prasad, B.V.V, Palzkill, T. | Deposit date: | 2022-04-13 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M beta-lactamase. Commun Biol, 6, 2023
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7TI0
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![BU of 7ti0 by Molmil](/molmil-images/mine/7ti0) | Structure of CTX-M-15 bound to RPX-7063 at 1.5A | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Clifton, M.C, Abendroth, J, Hecker, S.J, Edwards, T.E. | Deposit date: | 2022-01-12 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022
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7U4B
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![BU of 7u4b by Molmil](/molmil-images/mine/7u4b) | Ampicillin-CTX-M-15 | Descriptor: | (2S,4S)-2-[(1S)-1-{[(2S)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, SULFATE ION | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U57
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![BU of 7u57 by Molmil](/molmil-images/mine/7u57) | apo-CTX-M-15 | Descriptor: | Beta-lactamase, SULFATE ION | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-03-01 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U49
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![BU of 7u49 by Molmil](/molmil-images/mine/7u49) | DFC-CTX-M-15 | Descriptor: | (2R,4S,5R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-5-(sulfanylmethyl)-1,3-thiazinane-4-carboxylic acid, Beta-lactamase | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7U48
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![BU of 7u48 by Molmil](/molmil-images/mine/7u48) | Clavulanic acid-CTX-M-15 | Descriptor: | (E)-5-hydroxy-3-oxo-N-(3-oxopropylidene)-L-norvaline, Beta-lactamase, GLYCEROL, ... | Authors: | Ahmadvand, P, Kang, C.H. | Deposit date: | 2022-02-28 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. Int J Mol Sci, 23, 2022
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7TI2
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![BU of 7ti2 by Molmil](/molmil-images/mine/7ti2) | Structure of KPC-2 bound to RPX-7063 at 1.75A | Descriptor: | 1,2-ETHANEDIOL, Carbapenem-hydrolyzing beta-lactamase KPC, {(3R,7S)-2-hydroxy-3-[2-(thiophen-2-yl)acetamido]-2,3,4,7-tetrahydro-1,2-oxaborepin-7-yl}acetic acid | Authors: | Clifton, M.C, Fairman, J.W, Edwards, T.E, Hecker, S.J. | Deposit date: | 2022-01-12 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62, 2022
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5GLD
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![BU of 5gld by Molmil](/molmil-images/mine/5gld) | Crystal structure of the class A beta-lactamase PenL-tTR11 in complex with CBA | Descriptor: | Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | Authors: | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | Deposit date: | 2016-07-10 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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5GLA
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![BU of 5gla by Molmil](/molmil-images/mine/5gla) | Crystal structure of the class A beta-lactamase PenL-tTR10 containing 10 residues insertion in omega-loop | Descriptor: | Beta-lactamase | Authors: | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | Deposit date: | 2016-07-10 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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5GL9
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![BU of 5gl9 by Molmil](/molmil-images/mine/5gl9) | Crystal structure of the class A beta-lactamase PenL | Descriptor: | Beta-lactamase, GLYCEROL | Authors: | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | Deposit date: | 2016-07-10 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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5GLB
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![BU of 5glb by Molmil](/molmil-images/mine/5glb) | Crystal structure of the class A beta-lactamase PenL-tTR10 in complex with CBA | Descriptor: | Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | Authors: | Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. | Deposit date: | 2016-07-10 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
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5HW5
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![BU of 5hw5 by Molmil](/molmil-images/mine/5hw5) | |