PDB: 10243 resultsInfo pagesStatus searchChemie searchBIRD

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5JQ8	Crystal structure of CDK2 in complex with inhibitor ICEC0943 Descriptor: (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, Cyclin-dependent kinase 2 Authors: Hazel, P, Freemont, P.S. Deposit date: 2016-05-04 Release date: 2017-02-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem, 12, 2017
8HZS	Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-09 Release date: 2024-01-10 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) To Be Published
5K4J	Crystal Structure of CDK2 in complex with compound 22 Descriptor: 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Cyclin-dependent kinase 2 Authors: Yin, J, Wang, W. Deposit date: 2016-05-20 Release date: 2016-07-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59, 2016
7UPN	Maedi visna virus Vif in complex with CypA and E3 ubiquitin ligase Descriptor: Elongin-B, Elongin-C, Peptidyl-prolyl cis-trans isomerase A, ... Authors: Hu, Y, Xiong, Y. Deposit date: 2022-04-16 Release date: 2023-01-25 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif. Sci Adv, 9, 2023
7TAN	Structure of VRK1 C-terminal tail bound to nucleosome core particle Descriptor: Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, Histone H3.2, ... Authors: Spangler, C.J, Budziszewski, G.R, McGinty, R.K. Deposit date: 2021-12-21 Release date: 2022-05-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3 Å) Cite: Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity. Nucleic Acids Res., 50, 2022
9C62	P400 subcomplex of the native human TIP60 complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... Authors: Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. Deposit date: 2024-06-07 Release date: 2024-08-21 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (5.28 Å) Cite: Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. Deposit date: 2016-07-01 Release date: 2016-08-17 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (4.35 Å) Cite: An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016
5GJR	An atomic structure of the human 26S proteasome Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. Deposit date: 2016-07-01 Release date: 2016-09-07 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016
7XJG	Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.5 angstrom Descriptor: DNA (105-MER), MAGNESIUM ION, RNA (14-MER), ... Authors: Wang, Y.J, Guan, Z.Y, Zou, T.T. Deposit date: 2022-04-17 Release date: 2022-09-14 Last modified: 2025-06-25 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism. Nat Microbiol, 7, 2022
5D1B	Crystal structure of G117E HDAC8 in complex with TSA Descriptor: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... Authors: Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2015-08-04 Release date: 2015-10-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
5D1D	Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate Descriptor: HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, POTASSIUM ION, ... Authors: Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2015-08-04 Release date: 2015-10-21 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.011 Å) Cite: Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54, 2015
5D1J	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032) Descriptor: Cyclin-dependent kinase 2, N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide Authors: Sack, J.S. Deposit date: 2015-08-04 Release date: 2015-08-12 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: N-(Cycloalkylamino)Acyl-2-Aminothiazole Inhibitors Of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl) -2-Oxazolyl]Methyl]Thio]-2-Thiazolyl]-4-Piperidinecarboxamide (Bms-387032), A Highly Efficacious And Selective Antitumor Agent J.Med.Chem., 47, 2004
5DCG	Crystal Structure of WT Apo Human Glutathione Transferase Pi Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Glutathione S-transferase P, ... Authors: Parker, L.J, Parker, M.W, Morton, C.J. Deposit date: 2015-08-24 Release date: 2016-12-07 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics To Be Published
7VVZ	NuA4 bound to the nucleosome Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... Authors: Qu, K, Chen, Z. Deposit date: 2021-11-09 Release date: 2022-08-10 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (8.8 Å) Cite: Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Nature, 610, 2022
8Q7E	Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly Descriptor: Cullin-9, E3 ubiquitin-protein ligase RBX1 Authors: Hopf, L.V.M, Horn-Ghetko, D, Schulman, B.A. Deposit date: 2023-08-16 Release date: 2024-04-17 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nat.Struct.Mol.Biol., 31, 2024
6RNY	PFV intasome - nucleosome strand transfer complex Descriptor: DNA (108-MER), DNA (128-MER), DNA (33-MER), ... Authors: Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. Deposit date: 2019-05-09 Release date: 2019-09-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
6HTS	Cryo-EM structure of the human INO80 complex bound to nucleosome Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... Authors: Ayala, R, Willhoft, O, Aramayo, R.J, Wilkinson, M, McCormack, E.A, Ocloo, L, Wigley, D.B, Zhang, X. Deposit date: 2018-10-04 Release date: 2018-11-07 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structure and regulation of the human INO80-nucleosome complex. Nature, 556, 2018
3DS6	P38 complex with a phthalazine inhibitor Descriptor: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide Authors: Herberich, B, Syed, R, Li, V, Grosfeld, D. Deposit date: 2008-07-11 Release date: 2008-10-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008
8UXQ	Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome Descriptor: Chromobox protein homolog 5, DNA Widom601 (208bp) strand1, DNA Widom601 (208bp) strand2, ... Authors: Tan, D, Sokolova, V. Deposit date: 2023-11-09 Release date: 2024-09-25 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (6.3 Å) Cite: Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction. Structure, 32, 2024
8H1T	Cryo-EM structure of BAP1-ASXL1 bound to chromatosome Descriptor: DNA (187-MER), Histone H1.4, Histone H2A type 1-D, ... Authors: Ge, W, Yu, C, Xu, R.M. Deposit date: 2022-10-04 Release date: 2023-02-01 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3 Å) Cite: Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 616, 2023
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 Descriptor: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... Authors: Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. Deposit date: 2020-12-04 Release date: 2021-02-10 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
2EXU	Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... Authors: Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. Deposit date: 2005-11-08 Release date: 2006-11-08 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain To be published
8JRT	Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) bound to K11/K48-branched ubiquitin (Ub) chain composed of three Ub. Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Hsu, S.T.D, Draczkowski, P, Wang, Y.S. Deposit date: 2023-06-17 Release date: 2024-12-18 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of human 26S proteasomal RP subcomplex bound with branched Ub chain. To Be Published
8JRI	Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Hsu, S.T.D, Draczkowski, P, Wang, Y.S. Deposit date: 2023-06-16 Release date: 2024-12-18 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryo-EM structure of human 26S proteasomal RP subcomplex bound with branched Ub chain. To Be Published
8JTI	Cryo-EM structure of human 26S RP (Eb state) bound to K11/K48-branched ubiquitin (Ub) chain composed of four Ub. Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Hsu, S.T.D, Draczkowski, P, Wang, Y.S. Deposit date: 2023-06-21 Release date: 2024-12-25 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structure of human 26S proteasomal RP subcomplex bound with branched Ub chain. To Be Published

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