5JQ8
Crystal structure of CDK2 in complex with inhibitor ICEC0943
Summary for 5JQ8
| Entry DOI | 10.2210/pdb5jq8/pdb |
| Descriptor | Cyclin-dependent kinase 2, (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol (3 entities in total) |
| Functional Keywords | kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
| Total number of polymer chains | 1 |
| Total formula weight | 34371.00 |
| Authors | Hazel, P.,Freemont, P.S. (deposition date: 2016-05-04, release date: 2017-02-08, Last modification date: 2024-01-10) |
| Primary citation | Hazel, P.,Kroll, S.H.,Bondke, A.,Barbazanges, M.,Patel, H.,Fuchter, M.J.,Coombes, R.C.,Ali, S.,Barrett, A.G.,Freemont, P.S. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem, 12:372-380, 2017 Cited by PubMed: 28125165DOI: 10.1002/cmdc.201600535 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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