5W3S
 
 | | Cryo-electron microscopy structure of a TRPML3 ion channel | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Mucolipin-3 isoform 1, ... | | Authors: | Hirschi, M, Herzik, M.A, Wie, J, Suo, Y, Borschel, W.F, Ren, D, Lander, G.C, Lee, S.Y. | | Deposit date: | 2017-06-08 | | Release date: | 2017-10-11 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Nature, 550, 2017
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6DJR
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6BWD
 | | 3.7 angstrom cryoEM structure of truncated mouse TRPM7 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, MAGNESIUM ION, Transient receptor potential cation channel subfamily M member 7 | | Authors: | Zhang, J, Li, Z, Duan, J, Li, J, Hulse, R.E, Santa-Cruz, A, Abiria, S.A, Krapivinsky, G, Clapham, D.E. | | Deposit date: | 2017-12-14 | | Release date: | 2018-08-15 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WJ9
 | | Human TRPML1 channel structure in agonist-bound open conformation | | Descriptor: | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | | Authors: | Schmiege, P, Li, X. | | Deposit date: | 2017-07-21 | | Release date: | 2017-10-18 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Human TRPML1 channel structures in open and closed conformations.
Nature, 550, 2017
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5WJ5
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3FRW
 | | Crystal structure of putative TrpR protein from Ruminococcus obeum | | Descriptor: | ACETATE ION, Putative Trp repressor protein | | Authors: | Osipiuk, J, Keigher, L, Jedrzejczak, R, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-01-08 | | Release date: | 2009-01-20 | | Last modified: | 2020-01-22 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | X-ray crystal structure of putative TrpR protein from Ruminococcus obeum.
To be Published
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3KOR
 | | Crystal structure of a putative Trp repressor from Staphylococcus aureus | | Descriptor: | Possible Trp repressor | | Authors: | Lam, R, Vodsedalek, J, Lam, K, Romanov, V, Battaile, K.P, Beletskaya, I, Pai, E.F, Chirgadze, N.Y. | | Deposit date: | 2009-11-13 | | Release date: | 2010-11-17 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of a putative Trp repressor from Staphylococcus aureus
To be Published
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7DYS
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6O6A
 | | Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state | | Descriptor: | CHOLESTEROL HEMISUCCINATE, SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | | Authors: | Diver, M.M, Cheng, Y, Julius, D. | | Deposit date: | 2019-03-05 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
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1TRQ
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6O6R
 | | Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state | | Descriptor: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | | Authors: | Diver, M.M, Cheng, Y, Julius, D. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
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6PKW
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry) | | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | | Authors: | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2019-06-30 | | Release date: | 2019-08-28 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6PKV
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry | | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | | Authors: | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2019-06-30 | | Release date: | 2019-08-28 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6PKX
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+ | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2019-06-30 | | Release date: | 2019-08-28 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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8E6T
 | | Human TRPM2 ion channel in 1 mM BR-ADPR | | Descriptor: | (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), Transient receptor potential cation channel subfamily M member 2 | | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | | Deposit date: | 2022-08-23 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition
To Be Published
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7RNT
 | | CRYSTAL STRUCTURE OF THE TYR45TRP MUTANT OF RIBONUCLEASE T1 IN A COMPLEX WITH 2'-ADENYLIC ACID | | Descriptor: | ADENOSINE-2'-MONOPHOSPHATE, CALCIUM ION, RIBONUCLEASE T1 | | Authors: | Koellner, G, Grunert, H.-P, Landt, O, Saenger, W. | | Deposit date: | 1991-08-20 | | Release date: | 1993-01-15 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the Tyr45Trp mutant of ribonuclease T1 in a complex with 2'-adenylic acid.
Eur.J.Biochem., 201, 1991
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8E6V
 | | MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement) | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, ZINC ION | | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | | Deposit date: | 2022-08-23 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition
To Be Published
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8E6Q
 | | Human TRPM2 ion channel in 1 mM ADPR | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | | Deposit date: | 2022-08-23 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition
To Be Published
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8E6S
 | | Human TRPM2 ion channel in 1 mM dADPR and Ca2+ | | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, ... | | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | | Deposit date: | 2022-08-23 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition
To Be Published
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8E6U
 | | Human TRPM2 ion channel in 1 mM F-dADPR | | Descriptor: | Transient receptor potential cation channel subfamily M member 2, [(2R,3S,5R)-5-(6-amino-8-phenyl-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) | | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | | Deposit date: | 2022-08-23 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition
To Be Published
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1GTN
 | | Structure of the trp RNA-binding attenuation protein (TRAP) bound to an RNA molecule containing 11 GAGCC repeats | | Descriptor: | (GAGCC)11G 56-NUCLEOTIDE RNA, TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN | | Authors: | Hopcroft, N.H, Wendt, A.L, Gollnick, P, Antson, A.A. | | Deposit date: | 2002-01-16 | | Release date: | 2002-04-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Specificity of Trap-RNA Interactions: Crystal Structures of Two Complexes with Different RNA Sequences
Acta Crystallogr.,Sect.D, 58, 2002
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1GTF
 | | The structure of the trp RNA-binding attenuation protein (TRAP) bound to a 53-nucleotide RNA molecule containing GAGUU repeats | | Descriptor: | (GAGUU)10GAG 53-NUCLEOTIDE RNA, TRP RNA-BINDING ATTENUATION PROTEIN (TRAP), TRYPTOPHAN | | Authors: | Hopcroft, N.H, Wendt, A.L, Gollnick, P, Antson, A.A. | | Deposit date: | 2002-01-15 | | Release date: | 2002-04-05 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Specificity of Trap-RNA Interactions: Crystal Structures of Two Complexes with Different RNA Sequences
Acta Crystallogr.,Sect.D, 58, 2002
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6G1K
 | | Electron cryo-microscopy structure of the canonical TRPC4 ion channel | | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily c member 4a | | Authors: | Vinayagam, D, Mager, T, Apelbaum, A, Bothe, A, Merino, F, Hofnagel, O, Gatsogiannis, C, Raunser, S. | | Deposit date: | 2018-03-21 | | Release date: | 2018-05-02 | | Last modified: | 2018-08-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Electron cryo-microscopy structure of the canonical TRPC4 ion channel.
Elife, 7, 2018
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6F55
 | | Complex structure of PACSIN SH3 domain and TRPV4 proline rich region | | Descriptor: | PACSIN 3, PRR | | Authors: | Glogowski, N.A, Goretzki, B, Diehl, E, Duchardt-Ferner, E, Hacker, C, Hellmich, U.A. | | Deposit date: | 2017-11-30 | | Release date: | 2018-10-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2.
Structure, 26, 2018
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7KCI
 | | DETERMINANTS OF REPRESSOR/OPERATOR RECOGNITION FROM THE STRUCTURE OF THE TRP OPERATOR BINDING SITE | | Descriptor: | Self-complementary deoxyoligonucleotide decamer d(CCACTAGTGG) | | Authors: | Shakked, Z, Guzikevich-Guerstein, G, Frolow, F, Rabinovich, D, Joachimiak, A, Sigler, P.B. | | Deposit date: | 1994-09-12 | | Release date: | 2020-10-14 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Determinants of repressor/operator recognition from the structure of the trp operator binding site.
Nature, 368, 1994
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