7B05

TRPC4 in complex with inhibitor GFB-8749

Summary for 7B05

Entry DOI	10.2210/pdb7b05/pdb
EMDB information	11957 4339
Descriptor	Transient receptor potential cation channel subfamily c member 4a, 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{H}-pyridazin-6-one, CALCIUM ION, ... (4 entities in total)
Functional Keywords	ion channel, trpc4, inhibitor, complex, membrane protein, transport protein
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	4
Total formula weight	423895.46
Authors	Vinayagam, D.,Quentin, D.,Sistel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Ledeboer, M.W.,Malojcic, G.,Raunser, S. (deposition date: 2020-11-18, release date: 2020-12-09)
Primary citation	Vinayagam, D.,Quentin, D.,Yu-Strzelczyk, J.,Sitsel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Yu, M.,Ledeboer, M.W.,Nagel, G.,Malojcic, G.,Raunser, S. Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9:-, 2020 Cited by PubMed: 33236980 DOI: 10.7554/eLife.60603 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation