8BV5
 
 | | Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | | Authors: | Khanppnavar, B, Korkhov, V.M. | | Deposit date: | 2023-01-04 | | Release date: | 2024-01-17 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics.
Embo Rep., 25, 2024
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7SX3
 | | Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | | Deposit date: | 2021-11-22 | | Release date: | 2021-12-29 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural architecture of the human NALCN channelosome.
Nature, 603, 2022
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7SX4
 | | Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | | Deposit date: | 2021-11-22 | | Release date: | 2021-12-29 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural architecture of the human NALCN channelosome.
Nature, 603, 2022
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8BFM
 | | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331 | | Descriptor: | Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, pyrazolo[5,1-a]phthalazin-6-amine | | Authors: | Kraemer, A, Zhu, W.F, Hernandez-Olmos, V, Proschak, E, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-10-26 | | Release date: | 2022-11-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2)
To Be Published
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8BUZ
 | | Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | | Authors: | Khanppnavar, B, Korkhov, V.M, Mehta, V. | | Deposit date: | 2022-12-01 | | Release date: | 2023-12-13 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics.
Embo Rep., 25, 2024
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2BKH
 | | Myosin VI nucleotide-free (MDInsert2) crystal structure | | Descriptor: | CALCIUM ION, CALMODULIN, GLYCEROL, ... | | Authors: | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2005-02-16 | | Release date: | 2005-06-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
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5U6Y
 | | Pseudo-atomic model of the CaMKIIa holoenzyme. | | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | | Authors: | Myers, J, Reichow, S.L. | | Deposit date: | 2016-12-09 | | Release date: | 2017-06-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (20 Å) | | Cite: | The CaMKII holoenzyme structure in activation-competent conformations.
Nat Commun, 8, 2017
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7REC
 | | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC | | Descriptor: | 5-hydroxydiclofenac, Calcium/calmodulin-dependent protein kinase type II subunit alpha, SODIUM ION | | Authors: | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | | Deposit date: | 2021-07-12 | | Release date: | 2021-07-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6W4O
 | | CaMKII alpha-30 Cryo-EM reconstruction | | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | | Authors: | Chao, L.H, Stratton, M.M. | | Deposit date: | 2020-03-11 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.
Sci.Signal., 13, 2020
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6W4P
 | | CaMKII alpha-30 Cryo-EM reconstruction - Class B | | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | | Authors: | Chao, L.H, Stratton, M.M. | | Deposit date: | 2020-03-11 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.
Sci.Signal., 13, 2020
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1MF8
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3O78
 | | The structure of Ca2+ Sensor (Case-12) | | Descriptor: | CALCIUM ION, Myosin light chain kinase, smooth muscle,Green fluorescent protein,Green fluorescent protein,Calmodulin-1 | | Authors: | Leder, L, Stark, W, Freuler, F, Marsh, M, Meyerhofer, M, Stettler, T, Mayr, L.M, Britanova, O.V, Strukova, L.A, Chudakov, D.M. | | Deposit date: | 2010-07-30 | | Release date: | 2010-09-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations
Sensors (Basel), 10, 2010
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6ALE
 | | A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model | | Descriptor: | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin-2, ... | | Authors: | Nam, Y.W, Zhang, M. | | Deposit date: | 2017-08-07 | | Release date: | 2018-08-08 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model.
Sci Rep, 8, 2018
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7MIR
 | | Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S. | | Deposit date: | 2021-04-17 | | Release date: | 2021-08-18 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural and mechanistic basis for protein glutamylation by the kinase fold.
Mol.Cell, 81, 2021
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6T6F
 | | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275) | | Descriptor: | 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide, Calcium/calmodulin-dependent protein kinase type 1D | | Authors: | Sorrell, F, Kraemer, A, Butterworth, S, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-10-18 | | Release date: | 2020-01-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | CAMK1D bound to CS275
To Be Published
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7UA3
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7U9T
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7UA4
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2BKI
 | | Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure | | Descriptor: | CALCIUM ION, CALMODULIN, SULFATE ION, ... | | Authors: | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2005-02-16 | | Release date: | 2005-06-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
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2BDW
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5YVC
 | | Structure of CaMKK2 in complex with CKI-012 | | Descriptor: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 2, ... | | Authors: | Niwa, H, Handa, N, Yokoyama, S. | | Deposit date: | 2017-11-24 | | Release date: | 2018-12-05 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
J.Mol.Graph.Model., 99, 2020
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5COC
 | | Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus | | Descriptor: | CALCIUM ION, Immunoglobulin G-binding protein A,Calmodulin | | Authors: | Jeong, W.H, Lee, H, Song, D.H, Lee, J.O. | | Deposit date: | 2015-07-20 | | Release date: | 2016-03-30 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.6691 Å) | | Cite: | Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker.
Nat Commun, 7, 2016
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2Y0A
 | | Structure of DAPK1 construct residues 1-304 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DEATH-ASSOCIATED PROTEIN KINASE 1 | | Authors: | Yumerefendi, H, Mas, P.J, Dordevic, N, McCarthy, A.A, Hart, D.J. | | Deposit date: | 2010-12-01 | | Release date: | 2011-12-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Library-Based Construct Screening of Death-Associated Protein Kinase 1 Identifies the Minimal Calmodulin Interaction Region and Autoinhibitory Conformation of the Catalytic Domain
To be Published
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8KA2
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3KL8
 | | CaMKIINtide Inhibitor Complex | | Descriptor: | Calcium/calmodulin dependent protein kinase II, Calcium/calmodulin-dependent protein kinase II inhibitor 1 | | Authors: | Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. | | Deposit date: | 2009-11-06 | | Release date: | 2010-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.372 Å) | | Cite: | Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Nat.Struct.Mol.Biol., 17, 2010
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