3MG0
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![BU of 3mg0 by Molmil](/molmil-images/mine/3mg0) | Structure of yeast 20S proteasome with bortezomib | Descriptor: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome component C1, Proteasome component C11, ... | Authors: | Sintchak, M.D. | Deposit date: | 2010-04-05 | Release date: | 2011-05-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit. Biochem.J., 430, 2010
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7SGJ
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7SGI
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7SGG
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7SGK
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8A1S
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![BU of 8a1s by Molmil](/molmil-images/mine/8a1s) | Structure of murine perforin-2 (Mpeg1) pore in twisted form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | Deposit date: | 2022-06-02 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
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8A1D
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![BU of 8a1d by Molmil](/molmil-images/mine/8a1d) | Structure of murine perforin-2 (Mpeg1) pore in ring form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | Deposit date: | 2022-06-01 | Release date: | 2022-07-20 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
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7S3V
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8AJ7
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![BU of 8aj7 by Molmil](/molmil-images/mine/8aj7) | Kunitz domain of Amblyomin-X | Descriptor: | 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X | Authors: | Ciccone, L, Servent, D, Stura, E.A. | Deposit date: | 2022-07-27 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front Mol Biosci, 10, 2023
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7U6B
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7U59
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7V1N
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![BU of 7v1n by Molmil](/molmil-images/mine/7v1n) | Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI | Descriptor: | Isoform Beta of Tissue factor pathway inhibitor, Toxin B | Authors: | Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. | Deposit date: | 2021-08-05 | Release date: | 2022-02-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
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7ZQS
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![BU of 7zqs by Molmil](/molmil-images/mine/7zqs) | Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... | Authors: | Bansia, H, Wang, T, Gutierrez, D, des Georges, A. | Deposit date: | 2022-05-02 | Release date: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing. J.Am.Chem.Soc., 144, 2022
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7U69
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7U3M
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7U6A
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7VOO
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![BU of 7voo by Molmil](/molmil-images/mine/7voo) | Induced alpha-2-macroglobulin monomer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Huang, X, Wang, Y, Ping, Z. | Deposit date: | 2021-10-14 | Release date: | 2022-10-19 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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8VC3
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![BU of 8vc3 by Molmil](/molmil-images/mine/8vc3) | Voltage gated potassium ion channel Kv1.2 in complex with DTx | Descriptor: | Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2 | Authors: | Wu, Y, Sigworth, F.J. | Deposit date: | 2023-12-13 | Release date: | 2024-07-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting. Biorxiv, 2024
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8WVB
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![BU of 8wvb by Molmil](/molmil-images/mine/8wvb) | Crystal structure of Lsd18 mutant S195M | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Putative epoxidase LasC | Authors: | Liu, N, Xiao, H.L, Chen, X. | Deposit date: | 2023-10-23 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A. Int J Mol Sci, 24, 2023
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8WVF
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![BU of 8wvf by Molmil](/molmil-images/mine/8wvf) | Crystal structure of Lsd18 mutant T189M and S195M | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative epoxidase LasC | Authors: | Liu, N, Xiao, H.L, Chen, X. | Deposit date: | 2023-10-23 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.757 Å) | Cite: | Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A. Int J Mol Sci, 24, 2023
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7VON
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![BU of 7von by Molmil](/molmil-images/mine/7von) | Native alpha-2-macroglobulin monomer | Descriptor: | Alpha-2-macroglobulin | Authors: | Huang, X, Wang, Y. | Deposit date: | 2021-10-14 | Release date: | 2022-11-16 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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3S93
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![BU of 3s93 by Molmil](/molmil-images/mine/3s93) | Crystal structure of conserved motif in TDRD5 | Descriptor: | Tudor domain-containing protein 5, UNKNOWN ATOM OR ION | Authors: | Chao, X, Tempel, W, Bian, C, Kania, J, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2011-05-31 | Release date: | 2011-08-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Crystal structure of conserved motif in TDRD5 to be published
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4QQG
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![BU of 4qqg by Molmil](/molmil-images/mine/4qqg) | Crystal structure of an N-terminal HTATIP fragment | Descriptor: | Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION | Authors: | Liu, Y, Tempel, W, Wernimont, A.K, Dobrovetsky, E, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-06-27 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and histone binding studies of the chromo barrel domain of TIP60. FEBS Lett., 592, 2018
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6U7R
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4TLV
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![BU of 4tlv by Molmil](/molmil-images/mine/4tlv) | CARDS TOXIN, NICKED | Descriptor: | ACETATE ION, ADP-ribosylating toxin CARDS, GLYCEROL, ... | Authors: | Taylor, A.B, Pakhomova, O.N, Hart, P.J. | Deposit date: | 2014-05-30 | Release date: | 2015-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae. Proc.Natl.Acad.Sci.USA, 112, 2015
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