PDB: 717 resultsInfo pagesStatus searchChemie searchBIRD

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8SLS	Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and ambient pressure (0.1 MPa) Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 Authors: Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A. Deposit date: 2023-04-24 Release date: 2023-06-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. Biorxiv, 2023
3QCL	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCM	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCD	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form Descriptor: ACETIC ACID, Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QKQ	Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3QCJ	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid Descriptor: 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCB	Human receptor protein tyrosine phosphatase gamma, domain 1, apo Descriptor: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCN	Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form Descriptor: Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCH	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]-N-(methylsulfonyl)thiophene-2-carboxamide Descriptor: 3-[(3,4-dichlorobenzyl)sulfanyl]-N-(methylsulfonyl)thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
8U1E	Apo protein tyrosine phosphatase 1B (PTP1B) at high resolution (1.43 A) in space group P43212 with two distinctly ordered chains Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Sharma, S, Mehlman, S.T, Keedy, D.A. Deposit date: 2023-08-31 Release date: 2023-09-27 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.43 Å) Cite: High-resolution double vision of the allosteric phosphatase PTP1B. Acta Crystallogr.,Sect.F, 80, 2024
3QCE	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid via soaking Descriptor: 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid, Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3OLR	PTPN22 in complex with consensus phospho-tyrosine peptide 1 Descriptor: SKAP2, Tyrosine-protein phosphatase non-receptor type 22 Authors: Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y. Deposit date: 2010-08-26 Release date: 2011-06-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure basis of LYP substrate specificity revealed by reverse alanine screening and crystallography To be Published
3OMH	Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide Descriptor: Src kinase-associated phosphoprotein 2, Tyrosine-protein phosphatase non-receptor type 22 Authors: Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y. Deposit date: 2010-08-26 Release date: 2011-06-29 Last modified: 2011-09-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate. J.Biol.Chem., 286, 2011
3S3H	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4 Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3F	Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3QKP	Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3S3K	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate Descriptor: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Tyrosine-protein phosphatase 10D Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3E	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3QCK	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCI	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide Descriptor: N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3SME	Structure of PTP1B inactivated by H2O2/bicarbonate Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Tanner, J.J, Singh, H. Deposit date: 2011-06-27 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133, 2011
2HNQ	CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B Descriptor: PROTEIN-TYROSINE PHOSPHATASE-1B, TUNGSTATE(VI)ION Authors: Barford, D, Flint, A.J, Tonks, N.K. Deposit date: 1994-09-28 Release date: 1994-12-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structure of human protein tyrosine phosphatase 1B. Science, 263, 1994
2HNP	CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B Descriptor: PROTEIN-TYROSINE PHOSPHATASE-1B Authors: Barford, D, Flint, A.J, Tonks, N.K. Deposit date: 1994-09-19 Release date: 1994-12-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structure of human protein tyrosine phosphatase 1B. Science, 263, 1994
6B8Z	Multiconformer model of WT PTP1B with BB3 at 273 K Descriptor: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Tyrosine-protein phosphatase non-receptor type 1 Authors: Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. Deposit date: 2017-10-09 Release date: 2018-06-20 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
2I5X	Engineering the PTPbeta catalytic domain with improved crystallization properties Descriptor: (4-ETHYLPHENYL)SULFAMIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M, Klopfenstein, S. Deposit date: 2006-08-26 Release date: 2006-09-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr.,Sect.D, 62, 2006

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