3OMH

Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide

Summary for 3OMH

Entry DOI	10.2210/pdb3omh/pdb
Related	2QCJ 2QCT
Descriptor	Tyrosine-protein phosphatase non-receptor type 22, Src kinase-associated phosphoprotein 2 (3 entities in total)
Functional Keywords	hydrolase, tyrosine phosphatase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm (By similarity): Q9Y2R2 Cytoplasm: O75563
Total number of polymer chains	8
Total formula weight	151636.26
Authors	Yu, X.,Sun, J.-P.,Zhang, S.,Zhang, Z.-Y. (deposition date: 2010-08-26, release date: 2011-06-29, Last modification date: 2011-09-14)
Primary citation	Yu, X.,Chen, M.,Zhang, S.,Yu, Z.H.,Sun, J.P.,Wang, L.,Liu, S.,Imasaki, T.,Takagi, Y.,Zhang, Z.Y. Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate. J.Biol.Chem., 286:30526-30534, 2011 Cited by PubMed: 21719704 DOI: 10.1074/jbc.M111.254722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation