3OMH

Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Tyrosine-protein phosphatase non-receptor type 22	polymer	313	36743.1	4	UniProt (Q9Y2R2) Pfam (PF00102)	Homo sapiens (human)	Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP
2	E, F, G, H (E, F, G, H)	Src kinase-associated phosphoprotein 2	polymer	9	1166.0	4	UniProt (O75563)	Homo sapiens	Src family-associated phosphoprotein 2, Src kinase-associated phosphoprotein 55-related protein, SKAP55 homolog, SKAP-55HOM, SKAP-HOM, Src-associated adapter protein with PH and SH3 domains, Pyk2/RAFTK-associated protein, Retinoic acid-induced protein 70
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 294 (UniProt: Q9Y2R2)

PDB	External Database	Details
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Ser 227	Cys 227	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	151636.3
All*	Total formula weight	151636.3

*Water molecules are not included.