3QCM

Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid

Summary for 3QCM

• Entry DOI: 10.2210/pdb3qcm/pdb
• Related: 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCN
• Descriptor: Receptor-type tyrosine-protein phosphatase gamma, 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: tyrosine receptor phosphatase, twisted mixed beta-sheets flanked by {alpha}-helices, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein (Probable): P23470
• Total number of polymer chains: 2
• Total formula weight: 72946.67

Authors

Sheriff, S. (deposition date: 2011-01-16, release date: 2011-12-28, Last modification date: 2023-09-13)

• Primary citation: Sheriff, S.,Beno, B.R.,Zhai, W.,Kostich, W.A.,McDonnell, P.A.,Kish, K.,Goldfarb, V.,Gao, M.,Kiefer, S.E.,Yanchunas, J.,Huang, Y.,Shi, S.,Zhu, S.,Dzierba, C.,Bronson, J.,Macor, J.E.,Appiah, K.K.,Westphal, R.S.,O'Connell, J.,Gerritz, S.W.; Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop; J.Med.Chem., 54:6548-6562, 2011; PubMed: 21882820; DOI: 10.1021/jm2003766

Experimental method

X-RAY DIFFRACTION (2.4 Å)