3QCM
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-type tyrosine-protein phosphatase gamma | polymer | 310 | 35735.6 | 2 | UniProt (P23470) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase gamma, R-PTP-gamma |
| 2 | C, E (A, B) | 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid | non-polymer | 542.5 | 2 | Chemie (NXW) | |||
| 3 | D, F (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A, B: 825 - 1128 (UniProt: P23470)
| PDB | External Database | Details |
|---|---|---|
| Gly 819 | - | expression tag |
| Ser 820 | - | expression tag |
| His 821 | - | expression tag |
| Met 822 | - | expression tag |
| Gly 823 | - | expression tag |
| Ser 824 | - | expression tag |
| Ile 948 | Val 948 | engineered mutation |
| Thr 970 | Ser 970 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71471.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1475.4 | |
| All* | Total formula weight | 72946.7 |
