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PDB: 155 results
5WXS
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BU of 5wxs by Molmil
Crystal structure of uPA in complex with S2444
Descriptor: (2R)-N-[2-[[(2S)-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-5-oxidanylidene-1,2-dihydropyrrole-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Jiang, L, Huang, M.
Deposit date:2017-01-08
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of uPA in complex with S2444
To Be Published
6NMB
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BU of 6nmb by Molmil
Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator
Descriptor: NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, Urokinase-type plasminogen activator
Authors:Law, R.H.P, Wu, G.
Deposit date:2019-01-10
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Blood Adv, 3, 2019
3PB1
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BU of 3pb1 by Molmil
Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator
Descriptor: Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, ...
Authors:Lin, Z, Jiang, L, Huang, M, Structure 2 Function Project (S2F)
Deposit date:2010-10-20
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.
J.Biol.Chem., 286, 2011
3OY6
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BU of 3oy6 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
Descriptor: MH036, Urokinase-type plasminogen activator
Authors:Jiang, L.G, Andreasen, P.A, Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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BU of 3oy5 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
Descriptor: MH027, SULFATE ION, Urokinase-type plasminogen activator
Authors:Jiang, L.G, Andreasen, P.A, Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
1OWD
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BU of 1owd by Molmil
Substituted 2-Naphthamidine inhibitors of urokinase
Descriptor: 6-[AMINO(IMINO)METHYL]-N-[(4R)-4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL]-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
Authors:Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
3KHV
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BU of 3khv by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
Descriptor: SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
Authors:Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-10-30
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
3KGP
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BU of 3kgp by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
Descriptor: 4-(aminomethyl)benzoic acid, SULFATE ION, Urokinase-type plasminogen activator
Authors:Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-10-29
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
1VJ9
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BU of 1vj9 by Molmil
Urokinase Plasminogen Activator B-Chain-JT464 Complex
Descriptor: N-(BENZYLSULFONYL)-L-SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}-O-BENZYL-L-SERINAMIDE, SULFATE ION, plasminogen activator, ...
Authors:Schweinitz, A, Steinmetzer, T, Banke, I.J, Arlt, M.J.E, Stuerzebecher, A, Schuster, O, Geissler, A, Giersiefen, H, Zeslawska, E, Jacob, U, Kruger, A, Stuerzebecher, J.
Deposit date:2004-02-03
Release date:2004-06-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents
J.Biol.Chem., 279, 2004
1SC8
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BU of 1sc8 by Molmil
Urokinase Plasminogen Activator B-Chain-J435 Complex
Descriptor: N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}GLYCINAMIDE, SULFATE ION, plasminogen activator, ...
Authors:Schweinitz, A, Steinmetzer, T, Banke, I.J, Arlt, M.J.E, Stuerzebecher, A, Schuster, O, Geissler, A, Giersiefen, H, Zeslawska, E, Jacob, U, Kruger, A, Stuerzebecher, J.
Deposit date:2004-02-12
Release date:2004-06-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents
J.Biol.Chem., 279, 2004
1W12
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BU of 1w12 by Molmil
UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor: N-((1S)-4-{[AMINO(IMINO)METHYL]AMINO}-1-FORMYLBUTYL)-2-{(3R)-3-[(BENZYLSULFONYL)AMINO]-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-1-YL}ACETAMIDE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Authors:Jacob, U.
Deposit date:2004-06-15
Release date:2008-05-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors.
J.Mol.Biol., 328, 2003
6AG3
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BU of 6ag3 by Molmil
Crystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
Descriptor: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
Authors:Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
Deposit date:2018-08-09
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:uPA-HMA
To Be Published
6L05
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BU of 6l05 by Molmil
Crystal structure of uPA_H99Y in complex with 50F
Descriptor: 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator
Authors:Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
Deposit date:2019-09-26
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of uPA_H99Y in complex with 50F
To Be Published
3BT2
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BU of 3bt2 by Molmil
Structure of urokinase receptor, urokinase and vitronectin complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
1LMW
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BU of 1lmw by Molmil
LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)
Descriptor: L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Authors:Spraggon, G.S, Phillips, C, Nowak, U.K, Ponting, C.P, Saunders, D, Dobson, C.M, Stuart, D.I, Jones, E.Y.
Deposit date:1995-07-26
Release date:1996-01-29
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure, 3, 1995
1F92
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BU of 1f92 by Molmil
UROKINASE PLASMINOGEN ACTIVATOR B CHAIN-UKI-1D COMPLEX
Descriptor: SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR, [2,4,6-TRIISOPROPYL-PHENYLSULFONYL-L-[3-AMIDINO-PHENYLALANINYL]]-N'-BETA-ALANINYL-PIPERAZINE
Authors:Zeslawska, E, Schweinitz, A, Karcher, A, Sondermann, P, Sperl, S, Sturzebecher, J, Jacob, U.
Deposit date:2000-07-06
Release date:2001-07-06
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.
J.Mol.Biol., 301, 2000
3KID
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BU of 3kid by Molmil
The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
Descriptor: Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate
Authors:Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-11-01
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
CHIN.J.STRUCT.CHEM., 28, 2009
2I9B
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BU of 2i9b by Molmil
Crystal structure of ATF-urokinase receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Urokinase plasminogen activator surface receptor, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2006-09-05
Release date:2007-01-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
3BT1
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BU of 3bt1 by Molmil
Structure of urokinase receptor, urokinase and vitronectin complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
1OWK
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BU of 1owk by Molmil
Substituted 2-Naphthamidine Inhibitors of Urokinase
Descriptor: 6-[(Z)-AMINO(IMINO)METHYL]-N-(1-ISOPROPYL-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL)-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
Authors:Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
1OWI
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BU of 1owi by Molmil
Substituted 2-Naphthamidine Inhibitors of Urokinase
Descriptor: 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE, Urokinase-type plasminogen activator
Authors:Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L.
Deposit date:2003-03-28
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47, 2004
4DW2
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BU of 4dw2 by Molmil
The crystal structure of uPA in complex with the Fab fragment of mAb-112
Descriptor: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator
Authors:Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
Deposit date:2012-02-24
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
5ZAH
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BU of 5zah by Molmil
uPA-BB2-30F
Descriptor: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
Authors:Buckley, B.J, Jiang, L.G, Huang, M.D, Kelso, M.J, Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5XG4
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BU of 5xg4 by Molmil
Crystal structure of uPA in complex with quercetin
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Urokinase-type plasminogen activator
Authors:Jiang, L, Huang, M.
Deposit date:2017-04-11
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structural mechanism of flavonoids in inhibiting serine proteases
Food Funct, 8, 2017
1FV9
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BU of 1fv9 by Molmil
Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole
Descriptor: 2-AMINO-5-HYDROXY-BENZIMIDAZOLE, SULFATE ION, UROKINASE
Authors:Nienaber, V.
Deposit date:2000-09-19
Release date:2000-10-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of novel inhibitors of urokinase via NMR-based screening.
J.Med.Chem., 43, 2000

222415

数据于2024-07-10公开中

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