6NMB

Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator

Summary for 6NMB

Entry DOI	10.2210/pdb6nmb/pdb
Descriptor	Urokinase-type plasminogen activator, NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywords	serine protease, fibrinolysis, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	128910.76
Authors	Law, R.H.P.,Wu, G. (deposition date: 2019-01-10, release date: 2019-03-06, Last modification date: 2024-10-30)
Primary citation	Wu, G.,Mazzitelli, B.A.,Quek, A.J.,Veldman, M.J.,Conroy, P.J.,Caradoc-Davies, T.T.,Ooms, L.M.,Tuck, K.L.,Schoenecker, J.G.,Whisstock, J.C.,Law, R.H.P. Tranexamic acid is an active site inhibitor of urokinase plasminogen activator. Blood Adv, 3:729-733, 2019 Cited by PubMed Abstract: TXA is an active-site inhibitor of uPA. TXA attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity. PubMed: 30814058 DOI: 10.1182/bloodadvances.2018025429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation