1F92

UROKINASE PLASMINOGEN ACTIVATOR B CHAIN-UKI-1D COMPLEX

Summary for 1F92

Entry DOI	10.2210/pdb1f92/pdb
Related	1EJN 1F5K 1F5L
Descriptor	UROKINASE-TYPE PLASMINOGEN ACTIVATOR, SULFATE ION, [2,4,6-TRIISOPROPYL-PHENYLSULFONYL-L-[3-AMIDINO-PHENYLALANINYL]]-N'-BETA-ALANINYL-PIPERAZINE, ... (4 entities in total)
Functional Keywords	urokinase, inhibitor, serine protease, human, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00749
Total number of polymer chains	1
Total formula weight	29249.30
Authors	Zeslawska, E.,Schweinitz, A.,Karcher, A.,Sondermann, P.,Sperl, S.,Sturzebecher, J.,Jacob, U. (deposition date: 2000-07-06, release date: 2001-07-06, Last modification date: 2021-11-03)
Primary citation	Zeslawska, E.,Schweinitz, A.,Karcher, A.,Sondermann, P.,Sperl, S.,Sturzebecher, J.,Jacob, U. Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design. J.Mol.Biol., 301:465-475, 2000 Cited by PubMed: 10926521 DOI: 10.1006/jmbi.2000.3966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation