5NN2
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![BU of 5nn2 by Molmil](/molmil-images/mine/5nn2) | The structure of the polo-box domain (PBD) of Plk1 in complex with Z228588490 | Descriptor: | (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid, Serine/threonine-protein kinase PLK1 | Authors: | Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M. | Deposit date: | 2017-04-07 | Release date: | 2018-02-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain. To Be Published
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3P2W
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![BU of 3p2w by Molmil](/molmil-images/mine/3p2w) | Unliganded form of Polo-like kinase I Polo-box domain | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1 | Authors: | Sledz, P, Hyvonen, M, Abell, C. | Deposit date: | 2010-10-04 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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3P34
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![BU of 3p34 by Molmil](/molmil-images/mine/3p34) | Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1, ... | Authors: | Sledz, P, Hyvonen, M, Abell, C. | Deposit date: | 2010-10-04 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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3P35
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![BU of 3p35 by Molmil](/molmil-images/mine/3p35) | |
4J53
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![BU of 4j53 by Molmil](/molmil-images/mine/4j53) | Crystal structure of PLK1 in complex with TAK-960 | Descriptor: | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ... | Authors: | Hosfield, D.J, Skene, R.J. | Deposit date: | 2013-02-07 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 23, 2013
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3P37
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4H71
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![BU of 4h71 by Molmil](/molmil-images/mine/4h71) | Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone) | Descriptor: | 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime, GLYCEROL, Serine/threonine-protein kinase PLK1 | Authors: | Yin, Z, Rehse, P.H. | Deposit date: | 2012-09-19 | Release date: | 2012-10-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box
Domain As a Phosphate Mimic Acs Chem.Biol., 8, 2013
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4J52
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![BU of 4j52 by Molmil](/molmil-images/mine/4j52) | Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor | Descriptor: | 4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ... | Authors: | Hosfield, D.J, Skene, R.J. | Deposit date: | 2013-02-07 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 23, 2013
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4H5X
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4HCO
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![BU of 4hco by Molmil](/molmil-images/mine/4hco) | |
4HAB
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![BU of 4hab by Molmil](/molmil-images/mine/4hab) | Crystal structure of Plk1 Polo-box domain in complex with PL-49 | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION, PL-49, ... | Authors: | Lee, W.C, Song, J.H, Kim, H.Y. | Deposit date: | 2012-09-26 | Release date: | 2013-04-03 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg.Med.Chem., 21, 2013
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3P2Z
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![BU of 3p2z by Molmil](/molmil-images/mine/3p2z) | Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1 | Descriptor: | GLYCEROL, Serine/threonine-protein kinase PLK1, phosphopeptide | Authors: | Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C. | Deposit date: | 2010-10-04 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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3P36
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![BU of 3p36 by Molmil](/molmil-images/mine/3p36) | Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1 | Descriptor: | GLYCEROL, PHOSPHATE ION, Serine/threonine-protein kinase PLK1, ... | Authors: | Sledz, P, Stubbs, C.J, Hyvonen, M, Abell, C. | Deposit date: | 2010-10-04 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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4HY2
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5J19
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![BU of 5j19 by Molmil](/molmil-images/mine/5j19) | phospho-Pon binding-induced Plk1 dimerization | Descriptor: | GLYCEROL, Phosphorylated peptide from Partner of Numb, Serine/threonine-protein kinase PLK1 | Authors: | Zhu, K, Shan, Z, Zhang, L, Wen, W. | Deposit date: | 2016-03-29 | Release date: | 2016-06-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity Structure, 24, 2016
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6GY2
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![BU of 6gy2 by Molmil](/molmil-images/mine/6gy2) | |
5DMS
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![BU of 5dms by Molmil](/molmil-images/mine/5dms) | Mouse Polo-box domain and Emi2 (169-177) | Descriptor: | F-box only protein 43, Serine/threonine-protein kinase PLK1 | Authors: | Namgoong, S. | Deposit date: | 2015-09-09 | Release date: | 2015-10-28 | Method: | X-RAY DIFFRACTION (1.89999 Å) | Cite: | Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization. Sci Rep, 5, 2015
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5X3S
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![BU of 5x3s by Molmil](/molmil-images/mine/5x3s) | |
8JOQ
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3BZI
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![BU of 3bzi by Molmil](/molmil-images/mine/3bzi) | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | Descriptor: | 9 mer peptide from M-phase inducer phosphatase 3, FORMIC ACID, Serine/threonine-protein kinase PLK1 | Authors: | Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G. | Deposit date: | 2008-01-18 | Release date: | 2008-02-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization. Proc.Natl.Acad.Sci.Usa, 104, 2007
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5DMV
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![BU of 5dmv by Molmil](/molmil-images/mine/5dmv) | Polo-box domain of Mouse Polo-like kinase 1 complexed with Emi2 (146-177) | Descriptor: | F-box only protein 43, NICKEL (II) ION, Serine/threonine-protein kinase PLK1 | Authors: | Namgoong, S. | Deposit date: | 2015-09-09 | Release date: | 2015-10-28 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization. Sci Rep, 5, 2015
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5DNJ
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![BU of 5dnj by Molmil](/molmil-images/mine/5dnj) | Mouse Polo-box domain and Peptide analog 702 | Descriptor: | Serine/threonine-protein kinase PLK1, peptide 707-56A-SER-TPO-NH2 | Authors: | Namgoong, S, Han, Y.H. | Deposit date: | 2015-09-10 | Release date: | 2016-02-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization. Sci Rep, 5, 2015
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2OJX
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![BU of 2ojx by Molmil](/molmil-images/mine/2ojx) | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization | Descriptor: | Serine/threonine-protein kinase PLK1, Synthetic peptide | Authors: | Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G. | Deposit date: | 2007-01-15 | Release date: | 2007-02-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3Q1I
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![BU of 3q1i by Molmil](/molmil-images/mine/3q1i) | Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... | Authors: | Sledz, P, Hyvonen, M, Abell, C. | Deposit date: | 2010-12-17 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angew.Chem.Int.Ed.Engl., 50, 2011
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