Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4J53

Crystal structure of PLK1 in complex with TAK-960

Summary for 4J53
Entry DOI10.2210/pdb4j53/pdb
Related4J52
DescriptorSerine/threonine-protein kinase PLK1, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywordsprotein serine/threonine kinase, mitosis, oncogenesis, regulation of cell cycle, kinase domain, atp binding, nuclear, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P53350
Total number of polymer chains1
Total formula weight34438.44
Authors
Hosfield, D.J.,Skene, R.J. (deposition date: 2013-02-07, release date: 2013-05-29, Last modification date: 2024-02-28)
Primary citationNie, Z.,Feher, V.,Natala, S.,McBride, C.,Kiryanov, A.,Jones, B.,Lam, B.,Liu, Y.,Kaldor, S.,Stafford, J.,Hikami, K.,Uchiyama, N.,Kawamoto, T.,Hikichi, Y.,Matsumoto, S.,Amano, N.,Zhang, L.,Hosfield, D.,Skene, R.,Zou, H.,Cao, X.,Ichikawa, T.
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg.Med.Chem.Lett., 23:3662-3666, 2013
Cited by
PubMed: 23664874
DOI: 10.1016/j.bmcl.2013.02.083
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon