5NN2

The structure of the polo-box domain (PBD) of Plk1 in complex with Z228588490

Summary for 5NN2

Entry DOI	10.2210/pdb5nn2/pdb
Descriptor	Serine/threonine-protein kinase PLK1, (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid (3 entities in total)
Functional Keywords	plk1, pbd1, mitosis, small molecule, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P53350
Total number of polymer chains	1
Total formula weight	26998.72
Authors	Kunciw, D.L.,Rossmann, M.,Stokes, J.E.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-04-07, release date: 2018-02-21, Last modification date: 2023-03-29)
Primary citation	Sharma, P.,Mahen, R.,Rossmann, M.,Stokes, J.E.,Hardwick, B.,Huggins, D.J.,Emery, A.,Kunciw, D.L.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Sci Rep, 9:15930-15930, 2019 Cited by PubMed: 31685831 DOI: 10.1038/s41598-019-50702-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation