8THU
 
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6RYR
 | | Nucleosome-CHD4 complex structure (single CHD4 copy) | | Descriptor: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | | Authors: | Farnung, L, Ochmann, M, Cramer, P. | | Deposit date: | 2019-06-11 | | Release date: | 2020-07-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Elife, 9, 2020
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7K6Q
 | | Active state Dot1 bound to the H4K16ac nucleosome | | Descriptor: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Truong, D.M, Lee, R, Armache, J.-P, Boeke, J.D, Armache, K.-J. | | Deposit date: | 2020-09-21 | | Release date: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.
Science, 371, 2021
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8HY0
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8HXY
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7EA8
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3MGS
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7CRQ
 | | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | | Descriptor: | DNA (168-MER), Histone H2A, Histone H2B, ... | | Authors: | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | | Deposit date: | 2020-08-14 | | Release date: | 2020-10-21 | | Last modified: | 2021-03-03 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
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3C1C
 | | The effect of H3 K79 dimethylation and H4 K20 trimethylation on nucleosome and chromatin structure | | Descriptor: | Histone 2, H2bf, Histone H2A type 1, ... | | Authors: | Lu, X, Simon, M, Chodaparambil, J, Hansen, J, Shokat, K, Luger, K. | | Deposit date: | 2008-01-22 | | Release date: | 2008-10-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Nat.Struct.Mol.Biol., 15, 2008
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8ETV
 | | Class2 of the INO80-Hexasome complex | | Descriptor: | DNA (110-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. | | Deposit date: | 2022-10-17 | | Release date: | 2023-07-12 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
Science, 381, 2023
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4XUJ
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6KIU
 | | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | Authors: | Huang, J, Xue, H, Yao, T. | | Deposit date: | 2019-07-20 | | Release date: | 2019-09-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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7UX9
 | | Arabidopsis DDM1 bound to nucleosome (H2A.W, H2B, H3.3, H4, with 147 bp DNA) | | Descriptor: | ATP-dependent DNA helicase DDM1, DNA (antisense strand), DNA (sense strand), ... | | Authors: | Ipsaro, J.J, Adams, D.W, Joshua-Tor, L. | | Deposit date: | 2022-05-05 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation.
Cell, 186, 2023
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8GPN
 | | Human menin in complex with H3K79Me2 nucleosome | | Descriptor: | DNA (177-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Lin, J, Yu, D, Lam, W.H, Dang, S, Zhai, Y, Li, X.D. | | Deposit date: | 2022-08-26 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Menin "reads" H3K79me2 mark in a nucleosomal context.
Science, 379, 2023
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8G8G
 | | Interaction of H3 tail in LIN28B nucleosome with Oct4 | | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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7X3X
 | | Cryo-EM structure of N1 nucleosome-RA | | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Lifei, L, Kangjing, C, Chen, Z. | | Deposit date: | 2022-03-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
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7NKY
 | | RNA Polymerase II-Spt4/5-nucleosome-FACT structure | | Descriptor: | Chromatin elongation factor SPT4, DNA (138-MER), DNA (148-MER), ... | | Authors: | Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. | | Deposit date: | 2021-02-19 | | Release date: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of nucleosome transcription mediated by Chd1 and FACT.
Nat.Struct.Mol.Biol., 28, 2021
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7YRD
 | | histone methyltransferase | | Descriptor: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | | Authors: | Li, H, Wang, W.Y. | | Deposit date: | 2022-08-09 | | Release date: | 2023-08-16 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Mol.Cell, 83, 2023
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8SVF
 | | BAP1/ASXL1 bound to the H2AK119Ub Nucleosome | | Descriptor: | DNA/RNA (187-MER), DNA/RNA (327-MER), Histone H2A type 1, ... | | Authors: | Thomas, J.F, Valencia-Sanchez, M.I, Armache, K.-J. | | Deposit date: | 2023-05-16 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1.
Sci Adv, 9, 2023
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3KXB
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7K6P
 | | Active state Dot1 bound to the unacetylated H4 nucleosome | | Descriptor: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Truong, D.M, Lee, R, Armache, J.-P, Boeke, J.D, Armache, K.-J. | | Deposit date: | 2020-09-21 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.
Science, 371, 2021
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7SSA
 | | Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome | | Descriptor: | Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ... | | Authors: | Eek, P, Tan, S. | | Deposit date: | 2021-11-10 | | Release date: | 2023-04-05 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.
Mol.Cell, 83, 2023
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7CRP
 | | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) | | Descriptor: | DNA (168-MER), Histone H2A, Histone H2B, ... | | Authors: | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | | Deposit date: | 2020-08-14 | | Release date: | 2020-10-21 | | Last modified: | 2021-03-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
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6S01
 | | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | | Deposit date: | 2019-06-13 | | Release date: | 2019-12-18 | | Last modified: | 2020-01-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Nat.Struct.Mol.Biol., 27, 2020
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7XPX
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