4XUJ

Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound

Summary for 4XUJ

DescriptorHistone H3.2, Histone H4, Histone H2A, ... (10 entities in total)
Functional Keywordsnucleosome, ruthenium agent, dna-bindig protein-dna complex, dna-binding protein-dna complex, dna-binding protein/dna
Biological sourceXenopus laevis (African clawed frog)
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Cellular locationNucleus P84233 P62799 Q6AZJ8 P02281
Total number of polymer chains10
Total molecular weight199153.51
Authors
Adhireksan, Z.,Davey, C.A. (deposition date: 2015-01-26, release date: 2016-01-27, Last modification date: 2016-03-02)
Primary citation
Hanif, M.,Meier, S.M.,Adhireksan, Z.,Henke, H.,Martic, S.,Labib, M.,Kandioller, W.,Jakupec, M.A.,Kraatz, H.B.,Davey, C.A.,Keppler, B.K.,Hartinger, C.G.
Contrasting Cytotoxicity and Reactivity of RuII-Arene Complexes of Morpholine vs Thiomorpholine Substituted 3-Hydroxy-2-pyridone Ligands
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.18 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29060.4%3.6%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution