4XUJ
Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (C, G) | Histone H2A | polymer | 128 | 13907.2 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (D, H) | Histone H2B 1.1 | polymer | 125 | 13848.1 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 5 | I (I) | DNA (145-MER) | polymer | 145 | 44749.7 | 1 | synthetic construct | ||
| 6 | J (J) | DNA (145-MER) | polymer | 145 | 44740.6 | 1 | synthetic construct | ||
| 7 | K, N, O (C, G, H) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 8 | L, P, Q (D, H) | [(1,2,3,4,5,6-eta)-1-methyl-4-(propan-2-yl)benzene]ruthenium | non-polymer | 235.3 | 3 | Chemie (4A6) | |||
| 9 | M (E) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 10 | R (H) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
D, H: -2 - 122 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | variant |
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Ser 33 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 198135.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1018.4 | |
| All* | Total formula weight | 199153.5 |
