6Z03
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![BU of 6z03 by Molmil](/molmil-images/mine/6z03) | DNA Topoisomerase | Descriptor: | DNA topoisomerase I | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | Deposit date: | 2020-05-07 | Release date: | 2021-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
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6Z01
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![BU of 6z01 by Molmil](/molmil-images/mine/6z01) | DNA Topoisomerase | Descriptor: | CHLORIDE ION, DNA topoisomerase I | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | Deposit date: | 2020-05-07 | Release date: | 2021-11-17 | Last modified: | 2023-05-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
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1SEU
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![BU of 1seu by Molmil](/molmil-images/mine/1seu) | Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex | Descriptor: | 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | Authors: | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | Deposit date: | 2004-02-18 | Release date: | 2005-04-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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1T8I
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![BU of 1t8i by Molmil](/molmil-images/mine/1t8i) | Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex | Descriptor: | 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | Authors: | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | Deposit date: | 2004-05-12 | Release date: | 2005-05-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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1SC7
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![BU of 1sc7 by Molmil](/molmil-images/mine/1sc7) | Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex | Descriptor: | 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | Authors: | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | Deposit date: | 2004-02-11 | Release date: | 2005-04-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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3IGC
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![BU of 3igc by Molmil](/molmil-images/mine/3igc) | Smallpox virus topoisomerase-DNA transition state | Descriptor: | 5'-D(*AP*TP*TP*CP*C)-3', 5'-D(*CP*GP*GP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*GP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', ... | Authors: | Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2009-07-27 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic. Structure, 18, 2010
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2H7G
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![BU of 2h7g by Molmil](/molmil-images/mine/2h7g) | Structure of variola topoisomerase non-covalently bound to DNA | Descriptor: | 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*TP*A)-3', DNA topoisomerase 1 | Authors: | Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2006-06-02 | Release date: | 2006-08-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for specificity in the poxvirus topoisomerase. Mol.Cell, 23, 2006
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2H7F
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![BU of 2h7f by Molmil](/molmil-images/mine/2h7f) | Structure of variola topoisomerase covalently bound to DNA | Descriptor: | 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', DNA topoisomerase 1 | Authors: | Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2006-06-02 | Release date: | 2006-08-15 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for specificity in the poxvirus topoisomerase. Mol.Cell, 23, 2006
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2GAJ
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![BU of 2gaj by Molmil](/molmil-images/mine/2gaj) | |
6PCM
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![BU of 6pcm by Molmil](/molmil-images/mine/6pcm) | |
5D5H
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![BU of 5d5h by Molmil](/molmil-images/mine/5d5h) | Crystal structure of Mycobacterium tuberculosis Topoisomerase I | Descriptor: | ACETATE ION, DNA topoisomerase 1, GLYCEROL, ... | Authors: | Tan, K, Cheng, B, Tse-Dinh, Y.C. | Deposit date: | 2015-08-10 | Release date: | 2015-12-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold. J.Mol.Biol., 428, 2016
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1NH3
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![BU of 1nh3 by Molmil](/molmil-images/mine/1nh3) | Human Topoisomerase I Ara-C Complex | Descriptor: | 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ... | Authors: | Chrencik, J.E, Burgin, A.B, Pommier, Y, Stewart, L, Redinbo, M.R. | Deposit date: | 2002-12-18 | Release date: | 2003-03-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex J.Biol.Chem., 278, 2003
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1OIS
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![BU of 1ois by Molmil](/molmil-images/mine/1ois) | YEAST DNA TOPOISOMERASE I, N-TERMINAL FRAGMENT | Descriptor: | DNA TOPOISOMERASE I | Authors: | Lue, N, Sharma, A, Mondragon, A, Wang, J.C. | Deposit date: | 1996-09-14 | Release date: | 1997-03-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications. Structure, 3, 1995
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1RRJ
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![BU of 1rrj by Molmil](/molmil-images/mine/1rrj) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | Authors: | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | Deposit date: | 2003-12-08 | Release date: | 2004-07-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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1R49
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![BU of 1r49 by Molmil](/molmil-images/mine/1r49) | Human topoisomerase I (Topo70) double mutant K532R/Y723F | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | Authors: | Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. | Deposit date: | 2003-10-03 | Release date: | 2003-12-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279, 2004
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1RR8
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![BU of 1rr8 by Molmil](/molmil-images/mine/1rr8) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | Authors: | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | Deposit date: | 2003-12-08 | Release date: | 2004-07-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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1TL8
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![BU of 1tl8 by Molmil](/molmil-images/mine/1tl8) | Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex | Descriptor: | 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM, 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | Authors: | Ioanoviciu, A, Antony, S, Pommier, Y, Staker, B.L, Stewart, L, Cushman, M. | Deposit date: | 2004-06-09 | Release date: | 2005-06-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis J.Med.Chem., 48, 2005
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1MW9
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![BU of 1mw9 by Molmil](/molmil-images/mine/1mw9) | |
1MW8
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![BU of 1mw8 by Molmil](/molmil-images/mine/1mw8) | |
3PWT
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![BU of 3pwt by Molmil](/molmil-images/mine/3pwt) | |
1YUA
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![BU of 1yua by Molmil](/molmil-images/mine/1yua) | |
1K4T
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![BU of 1k4t by Molmil](/molmil-images/mine/1k4t) | HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | Authors: | Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J. | Deposit date: | 2001-10-08 | Release date: | 2002-12-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The mechanism of topoisomerase I poisoning by a camptothecin analog Proc.Natl.Acad.Sci.USA, 99, 2002
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1K4S
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![BU of 1k4s by Molmil](/molmil-images/mine/1k4s) | HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | Descriptor: | 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ... | Authors: | Staker, B.L, Hjerrild, K, Feese, M.D, Behnke, C.A, Burgin Jr, A.B, Stewart, L.J. | Deposit date: | 2001-10-08 | Release date: | 2002-12-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The mechanism of topoisomerase I poisoning by a camptothecin analog Proc.Natl.Acad.Sci.USA, 99, 2002
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1LPQ
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![BU of 1lpq by Molmil](/molmil-images/mine/1lpq) | Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | Authors: | Lesher, D.T, Pommier, Y, Stewart, L, Redinbo, M.R. | Deposit date: | 2002-05-08 | Release date: | 2002-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | 8-Oxoguanine rearranges the active site of human topoisomerase I Proc.Natl.Acad.Sci.USA, 99, 2002
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2GAI
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![BU of 2gai by Molmil](/molmil-images/mine/2gai) | |