1K4S

HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Summary for 1K4S
Related1A31 1A35 1A36
Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ... (4 entities in total)
Functional Keywordscomplex (isomerase-dna), dna, topoisomerase i, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus: P11387
Total number of polymer chains4
Total formula weight85393.02
Authors
Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J. (deposition date: 2001-10-08, release date: 2002-12-04, Last modification date: 2011-07-13)
Primary citationBehnke, C.A.,Burgin Jr., A.B.,Feese, M.D.,Hjerrild, K.,Staker, B.L.,Stewart, L.J.
The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99:15387-15392, 2002
PubMed: 12426403
DOI: 110.1073/pnas.242259599
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation
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PDB entries from 2021-06-16