1K4S

HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Summary for 1K4S

• Entry DOI: 10.2210/pdb1k4s/pdb
• Related: 1A31 1A35 1A36
• Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ... (4 entities in total)
• Functional Keywords: complex (isomerase-dna), dna, topoisomerase i, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 4
• Total formula weight: 85393.02

Authors

Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J. (deposition date: 2001-10-08, release date: 2002-12-04, Last modification date: 2023-11-15)

• Primary citation: Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J.; The mechanism of topoisomerase I poisoning by a camptothecin analog; Proc.Natl.Acad.Sci.USA, 99:15387-15392, 2002; PubMed: 12426403; DOI: 10.1073/pnas.242259599

Experimental method

X-RAY DIFFRACTION (3.2 Å)