PDB: 47038 resultsInfo pagesStatus searchChemie searchBIRD

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3MN2	The crystal structure of a probable AraC family transcriptional regulator from Rhodopseudomonas palustris CGA009 Descriptor: PHOSPHATE ION, probable AraC family transcriptional regulator Authors: Tan, K, Li, H, Buck, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2010-04-20 Release date: 2010-05-12 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The crystal structure of a probable AraC family transcriptional regulator from Rhodopseudomonas palustris CGA009 To be Published
2VV2	hPPARgamma Ligand binding domain in complex with 5-HEPA Descriptor: (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Authors: Itoh, T, Fairall, L, Schwabe, J.W.R. Deposit date: 2008-06-02 Release date: 2008-08-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15, 2008
7N9F	Structure of the in situ yeast NPC Descriptor: Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ... Authors: Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S. Deposit date: 2021-06-17 Release date: 2022-01-26 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (37 Å) Cite: Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
3OMK	Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide Descriptor: (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1 Authors: Rudolph, M.G. Deposit date: 2010-08-27 Release date: 2011-01-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties Bioorg.Med.Chem.Lett., 21, 2011
3OKH	Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid Descriptor: 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1 Authors: Rudolph, M.G. Deposit date: 2010-08-25 Release date: 2010-12-29 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes Bioorg.Med.Chem.Lett., 21, 2010
7NXZ	Synthetic glycoform of Human Interleukin 6 Descriptor: Interleukin-6 Authors: Weyand, M, Unverzagt, C. Deposit date: 2021-03-19 Release date: 2021-04-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance. Angew.Chem.Int.Ed.Engl., 60, 2021
3NEU	The crystal structure of a functionally-unknown protein lin1836 from Listeria innocua Clip11262 Descriptor: GLYCEROL, Lin1836 protein Authors: Tan, K, Li, H, Gu, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2010-06-09 Release date: 2010-08-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.58 Å) Cite: The crystal structure of a functionally-unknown protein lin1836 from Listeria innocua Clip11262 To be Published
2WUI	Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. Descriptor: TRANSCRIPTIONAL REGULATOR Authors: Alguel, Y, Lu, D, Quade, N, Zhang, X. Deposit date: 2009-10-05 Release date: 2010-08-18 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of Mexz, a Key Repressor Responsible for Antibiotic Resistance in Pseudomonas Aeruginosa. J.Struct.Biol., 172, 2010
2X4H	Crystal Structure of the hypothetical protein SSo2273 from Sulfolobus solfataricus Descriptor: HYPOTHETICAL PROTEIN SSO2273, ZINC ION Authors: Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H. Deposit date: 2010-01-31 Release date: 2010-07-21 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
8EYT	30S_delta_ksgA+KsgA complex Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Sun, J, Kinman, L.F, Jahagirdar, D, Ortega, J, Davis, J.H. Deposit date: 2022-10-28 Release date: 2023-09-06 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion. Nat.Struct.Mol.Biol., 30, 2023
2VSR	hPPARgamma Ligand binding domain in complex with 9-(S)-HODE Descriptor: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Authors: Itoh, T, Fairall, L, Schwabe, J.W.R. Deposit date: 2008-04-29 Release date: 2008-08-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15, 2008
3PAS	Crystal structure of a TetR family transcription regulator (Maqu_1417) from MARINOBACTER AQUAEOLEI VT8 at 1.90 A resolution Descriptor: ACETATE ION, S-1,2-PROPANEDIOL, TetR family transcription regulator Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2010-10-19 Release date: 2010-11-17 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of a TetR family transcription regulator (Maqu_1417) from MARINOBACTER AQUAEOLEI VT8 at 1.90 A resolution To be published
4HV5	Structure of the MNTR FE2+ complex with E site metal binding Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FE (II) ION, Transcriptional regulator MntR Authors: Glasfeld, A, Brophy, M.B, Kliegman, J.I, Griner, S.L. Deposit date: 2012-11-05 Release date: 2012-11-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Roles of the A and C sites in the manganese-specific activation of MntR. Biochemistry, 52, 2013
7NUF	Vaccinia virus protein 018 in complex with STAT1 Descriptor: ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ... Authors: Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M. Deposit date: 2021-03-12 Release date: 2021-07-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.0004015 Å) Cite: Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Cell Host Microbe, 30, 2022
4HX4	Structure of MNTR mutant E11K complexed with Mn2+ Descriptor: MANGANESE (II) ION, TRANSCRIPTIONAL REGULATOR MNTR Authors: Glasfeld, A, McGuire, A. Deposit date: 2012-11-09 Release date: 2012-11-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Roles of the A and C Sites in the Manganese-Specific Activation of MntR. Biochemistry, 52, 2013
2OI4	Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Maksimoska, J, Meggers, E. Deposit date: 2007-01-10 Release date: 2007-04-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Org.Biomol.Chem., 5, 2007
4JAZ	Crystal structure of the complex between PPARgamma LBD and trans-resveratrol Descriptor: Peroxisome proliferator-activated receptor gamma, RESVERATROL Authors: Pochetti, G, Capelli, D, Montanari, R, Calleri, E, Moaddel, R, Temporini, C. Deposit date: 2013-02-19 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Resveratrol and Its Metabolites Bind to PPARs. Chembiochem, 15, 2014
2VST	hPPARgamma Ligand binding domain in complex with 13-(S)-HODE Descriptor: (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Authors: Itoh, T, Fairall, L, Schwabe, J.W.R. Deposit date: 2008-04-29 Release date: 2008-08-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15, 2008
2VV3	hPPARgamma Ligand binding domain in complex with 4-oxoDHA Descriptor: (6E,10Z,13Z,16Z,19Z)-4-oxodocosa-6,10,13,16,19-pentaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Authors: Itoh, T, Fairall, L, Schwabe, J.W.R. Deposit date: 2008-06-02 Release date: 2008-08-19 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids. Nat.Struct.Mol.Biol., 15, 2008
3QF9	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand Descriptor: 6-{5-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}naphthalene-1-carboxamide, CHLORIDE ION, Proto-oncogene serine/threonine-protein kinase pim-1, ... Authors: Filippakopoulos, P, Bullock, A.N, Fedorov, O, Miduturu, C.V, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Grey, N, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2011-01-21 Release date: 2011-03-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand To be Published
2XYW	Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy Descriptor: 3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, octyl beta-D-glucopyranoside Authors: Marquette, J.-P, Mathieu, M. Deposit date: 2010-11-19 Release date: 2011-02-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.14 Å) Cite: Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011
2V0V	Crystal Structure of Rev-Erb beta Descriptor: ORPHAN NUCLEAR RECEPTOR NR1D2 Authors: Woo, E.-J, Jeong, D.G, Lim, M.-Y, Jun Kim, S, Eon Ryu, S. Deposit date: 2007-05-19 Release date: 2007-10-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Insight Into the Constitutive Repression Function of the Nuclear Receptor Rev-Erbbeta J.Mol.Biol., 373, 2007
2XYX	Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy Descriptor: 4-[2-[[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]AMINO]ETHYL]-N-(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA, octyl beta-D-glucopyranoside Authors: Marquette, J.-P, Mathieu, M. Deposit date: 2010-11-19 Release date: 2011-02-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy Chemmedchem, 6, 2011
3NQO	Crystal structure of a MarR family transcriptional regulator (CD1569) from Clostridium difficile 630 at 2.20 A resolution Descriptor: GLYCEROL, MarR-family transcriptional regulator, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2010-06-29 Release date: 2010-07-21 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of a MarR family transcriptional regulator (CD1569) from Clostridium difficile 630 at 2.20 A resolution To be published
3R4K	Crystal structure of a putative ICLR transcriptional regulator (TM1040_3717) from SILICIBACTER SP. TM1040 at 2.46 A resolution Descriptor: 1,2-ETHANEDIOL, Transcriptional regulator, IclR family Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2011-03-17 Release date: 2011-04-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Crystal structure of a putative ICLR transcriptional regulator (TM1040_3717) from SILICIBACTER SP. TM1040 at 2.46 A resolution To be published

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