3QF9

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand

Summary for 3QF9

• Entry DOI: 10.2210/pdb3qf9/pdb
• Descriptor: Proto-oncogene serine/threonine-protein kinase pim-1, pimtide, 6-{5-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}naphthalene-1-carboxamide, ... (6 entities in total)
• Functional Keywords: transferase/peptide, complex transferase-peptide, pim1, kinase, cancer, leukemia, atp-binding, nuclear protein, nucleotide-binding, phosphorylation, proto-oncogene, serine/threonine-protein kinase, transferase, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 2
• Total formula weight: 37876.46

Authors

Filippakopoulos, P.,Bullock, A.N.,Fedorov, O.,Miduturu, C.V.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Grey, N.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-01-21, release date: 2011-03-02, Last modification date: 2023-09-13)

• Primary citation: Filippakopoulos, P.,Bullock, A.N.,Fedorov, O.,Miduturu, C.V.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Grey, N.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)