2OI4
Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole
Summary for 2OI4
| Entry DOI | 10.2210/pdb2oi4/pdb |
| Related | 1YHS 2BZH 2BZI 2BZJ |
| Descriptor | Proto-oncogene serine/threonine-protein kinase Pim-1, CHLORIDE ION, FLUORINATED PYRIDOCARBAZOLE CYCLOPENTADIENYL RU(CO) COMPLEX, ... (6 entities in total) |
| Functional Keywords | transferase, pim1, kinase, atp-binding, phosphorylation |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
| Total number of polymer chains | 1 |
| Total formula weight | 36590.99 |
| Authors | Maksimoska, J.,Meggers, E. (deposition date: 2007-01-10, release date: 2007-04-10, Last modification date: 2023-12-27) |
| Primary citation | Pagano, N.,Maksimoska, J.,Bregman, H.,Williams, D.S.,Webster, R.D.,Xue, F.,Meggers, E. Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Org.Biomol.Chem., 5:1218-1227, 2007 Cited by PubMed: 17406720DOI: 10.1039/b700433h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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