2OI4
Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole
Functional Information from GO Data
Chain | GOid | namespace | contents |
X | 0004672 | molecular_function | protein kinase activity |
X | 0004674 | molecular_function | protein serine/threonine kinase activity |
X | 0005515 | molecular_function | protein binding |
X | 0005524 | molecular_function | ATP binding |
X | 0005634 | cellular_component | nucleus |
X | 0005654 | cellular_component | nucleoplasm |
X | 0005730 | cellular_component | nucleolus |
X | 0005737 | cellular_component | cytoplasm |
X | 0005829 | cellular_component | cytosol |
X | 0005886 | cellular_component | plasma membrane |
X | 0006338 | biological_process | chromatin remodeling |
X | 0006468 | biological_process | protein phosphorylation |
X | 0006915 | biological_process | apoptotic process |
X | 0008134 | molecular_function | transcription factor binding |
X | 0016310 | biological_process | phosphorylation |
X | 0022898 | biological_process | regulation of transmembrane transporter activity |
X | 0030145 | molecular_function | manganese ion binding |
X | 0043024 | molecular_function | ribosomal small subunit binding |
X | 0043066 | biological_process | negative regulation of apoptotic process |
X | 0043433 | biological_process | negative regulation of DNA-binding transcription factor activity |
X | 0044024 | molecular_function | histone H2AS1 kinase activity |
X | 0045824 | biological_process | negative regulation of innate immune response |
X | 0045893 | biological_process | positive regulation of DNA-templated transcription |
X | 0046777 | biological_process | protein autophosphorylation |
X | 0046872 | molecular_function | metal ion binding |
X | 0050821 | biological_process | protein stabilization |
X | 0060045 | biological_process | positive regulation of cardiac muscle cell proliferation |
X | 0070561 | biological_process | vitamin D receptor signaling pathway |
X | 0071346 | biological_process | cellular response to type II interferon |
X | 0090336 | biological_process | positive regulation of brown fat cell differentiation |
X | 0106310 | molecular_function | protein serine kinase activity |
X | 1902033 | biological_process | regulation of hematopoietic stem cell proliferation |
X | 1904263 | biological_process | positive regulation of TORC1 signaling |
X | 1905062 | biological_process | positive regulation of cardioblast proliferation |
X | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL X 1001 |
Chain | Residue |
X | VAL69 |
X | GLU70 |
X | ARG73 |
X | THR196 |
X | EDO1002 |
X | HOH2794 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE JM1 X 1000 |
Chain | Residue |
X | VAL52 |
X | ALA65 |
X | LYS67 |
X | ILE104 |
X | LEU120 |
X | GLU121 |
X | ARG122 |
X | PRO123 |
X | GLU171 |
X | LEU174 |
X | ILE185 |
X | ASP186 |
X | LEU44 |
X | GLY45 |
X | PHE49 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO X 1002 |
Chain | Residue |
X | GLY47 |
X | GLY48 |
X | VAL69 |
X | ARG73 |
X | CL1001 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO X 1003 |
Chain | Residue |
X | LEU34 |
X | GLU35 |
X | VAL40 |
X | ILE66 |
X | HIS68 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO X 1004 |
Chain | Residue |
X | GLN257 |
X | ARG258 |
X | ASN286 |
X | HOH2850 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE EPE X 2691 |
Chain | Residue |
X | GLY48 |
X | PHE49 |
X | LYS67 |
X | VAL69 |
X | PRO87 |
X | GLU89 |
X | ASP167 |
X | ASP186 |
X | GLY188 |
X | SER189 |
X | ASP202 |
X | HOH2709 |
X | HOH2807 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK |
Chain | Residue | Details |
X | LEU44-LYS67 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI |
Chain | Residue | Details |
X | VAL163-ILE175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
X | ASP76 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 |
Chain | Residue | Details |
X | GLU30 | |
X | GLN37 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15657054 |
Chain | Residue | Details |
X | ASN7 | |
X | ASP170 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
X | ASP167 | |
X | GLU171 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
X | LYS169 | |
X | ASP167 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
X | THR204 | |
X | LYS169 | |
X | ASP167 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
X | ASN172 | |
X | LYS169 | |
X | ASP167 |