5HLT
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![BU of 5hlt by Molmil](/molmil-images/mine/5hlt) | Crystal structure of pyrene- and phenanthrene-modified DNA in complex with the BpuJ1 endonuclease binding domain | Descriptor: | DNA (5'-D(*GP*YPY*TP*AP*CP*CP*CP*GP*TP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*GP*GP*GP*TP*AP*YPY*C)-3'), Restriction endonuclease R.BpuJI | Authors: | Probst, M, Aeschimann, W, Chau, T.-T.-H, Langenegger, S.M, Stocker, A, Haener, R. | Deposit date: | 2016-01-15 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.672 Å) | Cite: | Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease. Nucleic Acids Res., 44, 2016
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5HHI
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![BU of 5hhi by Molmil](/molmil-images/mine/5hhi) | Structure of human DNA polymerase beta Host-Guest complexed with CBZ-platinated N7-G | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*AP*GP*GP*AP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | Authors: | Lee, S, Koag, M.-C. | Deposit date: | 2016-01-11 | Release date: | 2017-01-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.517 Å) | Cite: | Synthesis, structure, and biological evaluation of a platinum-carbazole conjugate. Chem Biol Drug Des, 91, 2018
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3LD6
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![BU of 3ld6 by Molmil](/molmil-images/mine/3ld6) | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole | Descriptor: | 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Lanosterol 14-alpha demethylase, ... | Authors: | Strushkevich, N, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-12 | Release date: | 2010-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of human CYP51 inhibition by antifungal azoles. J.Mol.Biol., 397, 2010
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6O5J
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![BU of 6o5j by Molmil](/molmil-images/mine/6o5j) | Crystal Structure of DAD2 bound to quinazolinone derivative | Descriptor: | 1-(4-hydroxy-3-nitrophenyl)quinazoline-2,4(1H,3H)-dione, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Hamiaux, C. | Deposit date: | 2019-03-03 | Release date: | 2019-06-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode. Biochem.J., 476, 2019
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7N5A
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![BU of 7n5a by Molmil](/molmil-images/mine/7n5a) | Structure of AtAtm3 in the closed conformation | Descriptor: | ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Fan, C, Rees, D.C. | Deposit date: | 2021-06-05 | Release date: | 2022-04-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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5HM7
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![BU of 5hm7 by Molmil](/molmil-images/mine/5hm7) | The Intracellular domain of Butyrophilin 3A1 protein | Descriptor: | BETA-MERCAPTOETHANOL, Butyrophilin subfamily 3 member A1, GLYCEROL, ... | Authors: | Adams, E.J, Gu, S. | Deposit date: | 2016-01-15 | Release date: | 2017-07-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V gamma 9V delta 2 T cell activation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3L8B
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![BU of 3l8b by Molmil](/molmil-images/mine/3l8b) | Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin | Descriptor: | DNA (5'-D(*AP*C*TP*(G35)P*TP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*A)-3'), DNA polymerase, ... | Authors: | Aller, P, Ye, Y, Wallace, S.S, Burrows, C.J, Doublie, S. | Deposit date: | 2009-12-30 | Release date: | 2010-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin. Biochemistry, 49, 2010
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5HME
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![BU of 5hme by Molmil](/molmil-images/mine/5hme) | |
3LDR
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![BU of 3ldr by Molmil](/molmil-images/mine/3ldr) | |
3LE7
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![BU of 3le7 by Molmil](/molmil-images/mine/3le7) | Crystal structure of PD-L1 from P. dioica in complex with adenine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Ribosome-inactivating protein PD-L1/PD-L2 | Authors: | Ruggiero, A, Berisio, R. | Deposit date: | 2010-01-14 | Release date: | 2010-04-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves Mol Biosyst, 6, 2010
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5HHO
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![BU of 5hho by Molmil](/molmil-images/mine/5hho) | Crystal Structure of the JM22 TCR in complex with HLA-A*0201 in complex with M1-G4E | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | Authors: | Gras, S, Josephs, T.M, Rossjohn, J. | Deposit date: | 2016-01-11 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc.Natl.Acad.Sci.USA, 113, 2016
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3L9L
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![BU of 3l9l by Molmil](/molmil-images/mine/3l9l) | Crystal structure of pka with compound 36 | Descriptor: | 5-[2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propyl}amino)-1,3-thiazol-5-yl]-1,3-dihydro-2H-indol-2-one, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | Authors: | Huang, X. | Deposit date: | 2010-01-05 | Release date: | 2011-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010
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5HMS
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![BU of 5hms by Molmil](/molmil-images/mine/5hms) | X-ray structure of human recombinant 5-aminolaevulinic acid dehydratase (hrALAD). | Descriptor: | Delta-aminolevulinic acid dehydratase, ZINC ION | Authors: | Butler, D, Erskine, P.T, Cooper, J.B, Shoolingin-Jordan, P.M. | Deposit date: | 2016-01-17 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis. Acta Crystallogr D Struct Biol, 73, 2017
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3LA1
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5HI0
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![BU of 5hi0 by Molmil](/molmil-images/mine/5hi0) | The Substrate Binding Mode and Chemical Basis of a Reaction Specificity Switch in Oxalate Decarboxylase | Descriptor: | COBALT (II) ION, OXALATE ION, Oxalate decarboxylase OxdC, ... | Authors: | Zhu, W, Easthon, L.M, Reinhardt, L.A, Tu, C, Cohen, S.E, Silverman, D.N, Allen, K.N, Richards, N.G.J. | Deposit date: | 2016-01-11 | Release date: | 2016-04-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase. Biochemistry, 55, 2016
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5HI6
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![BU of 5hi6 by Molmil](/molmil-images/mine/5hi6) | The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form | Descriptor: | CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... | Authors: | Chang, C, Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-01-11 | Release date: | 2016-02-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.051 Å) | Cite: | The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form To Be Published
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3LAE
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![BU of 3lae by Molmil](/molmil-images/mine/3lae) | The crystal structure of a functionally unknown conserved protein from Haemophilus influenzae Rd KW20 | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, UPF0053 protein HI0107, ... | Authors: | Tan, K, Li, H, Bargassa, M, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-01-06 | Release date: | 2010-01-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.453 Å) | Cite: | The crystal structure of a functionally unknown conserved protein from Haemophilus influenzae Rd KW20 To be Published
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5HN1
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![BU of 5hn1 by Molmil](/molmil-images/mine/5hn1) | Crystal structure of Interleukin-37 | Descriptor: | Interleukin-37, SULFATE ION | Authors: | Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C. | Deposit date: | 2016-01-17 | Release date: | 2017-02-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol, 2, 2017
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5HNB
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5HIC
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![BU of 5hic by Molmil](/molmil-images/mine/5hic) | EGFR kinase domain mutant "TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor | Descriptor: | Epidermal growth factor receptor, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION | Authors: | Eigenbrot, C, Yu, C. | Deposit date: | 2016-01-11 | Release date: | 2016-04-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
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3LAO
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![BU of 3lao by Molmil](/molmil-images/mine/3lao) | |
5HIK
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![BU of 5hik by Molmil](/molmil-images/mine/5hik) | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | Deposit date: | 2016-01-12 | Release date: | 2016-11-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity Sci Rep, 6, 2016
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5H5Z
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![BU of 5h5z by Molmil](/molmil-images/mine/5h5z) | Crystal structure of bony fish MHC class I, peptide and B2m II | Descriptor: | Beta-2-microglobulin, MHC class I antigen, peptide chain | Authors: | Chen, Z, Zhang, N, Qi, J, Li, X, Chen, R, Wang, Z, Gao, F.G, Xia, C. | Deposit date: | 2016-11-10 | Release date: | 2017-11-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | The Mechanism of beta 2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. Iscience, 23, 2020
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5HIQ
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5H6G
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![BU of 5h6g by Molmil](/molmil-images/mine/5h6g) | Crystal structure of a thermostable lipase from Marine Streptomyces | Descriptor: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Hou, S, Zhao, Z, Liu, J. | Deposit date: | 2016-11-11 | Release date: | 2017-09-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of a lipase from Streptomyces sp. strain W007 - implications for thermostability and regiospecificity FEBS J., 284, 2017
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