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3L9L

Crystal structure of pka with compound 36

Summary for 3L9L
Entry DOI10.2210/pdb3l9l/pdb
Related3L9M 3L9N
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propyl}amino)-1,3-thiazol-5-yl]-1,3-dihydro-2H-indol-2-one, ... (4 entities in total)
Functional Keywordspkb, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P17612
Total number of polymer chains4
Total formula weight86934.89
Authors
Huang, X. (deposition date: 2010-01-05, release date: 2011-01-19, Last modification date: 2023-09-06)
Primary citationZeng, Q.,Allen, J.G.,Bourbeau, M.P.,Wang, X.,Yao, G.,Tadesse, S.,Rider, J.T.,Yuan, C.C.,Hong, F.T.,Lee, M.R.,Zhang, S.,Lofgren, J.A.,Freeman, D.J.,Yang, S.,Li, C.,Tominey, E.,Huang, X.,Hoffman, D.,Yamane, H.K.,Fotsch, C.,Dominguez, C.,Hungate, R.,Zhang, X.
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20:1559-1564, 2010
Cited by
PubMed: 20137943
DOI: 10.1016/j.bmcl.2010.01.067
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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