6ZN5
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![BU of 6zn5 by Molmil](/molmil-images/mine/6zn5) | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2 | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-07-06 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
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2CV0
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2CV1
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![BU of 2cv1 by Molmil](/molmil-images/mine/2cv1) | Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu), ATP, and an analog of L-glutamate: a quaternary complex | Descriptor: | (4S)-4-AMINO-5-HYDROXYPENTANOIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-31 | Release date: | 2006-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu), ATP, and an analog of L-glutamate: a quaternary complex To be Published
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2CV2
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![BU of 2cv2 by Molmil](/molmil-images/mine/2cv2) | Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu) and an enzyme inhibitor, Glu-AMS | Descriptor: | CHLORIDE ION, MAGNESIUM ION, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE, ... | Authors: | Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-31 | Release date: | 2006-09-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase Structure, 14, 2006
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1SBQ
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![BU of 1sbq by Molmil](/molmil-images/mine/1sbq) | Crystal Structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae at 2.2 resolution | Descriptor: | 5,10-Methenyltetrahydrofolate synthetase homolog, SULFATE ION | Authors: | Chen, S, Shin, D.H, Pufan, R, Kim, R, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-02-10 | Release date: | 2004-08-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution Proteins, 56, 2004
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7TM3
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![BU of 7tm3 by Molmil](/molmil-images/mine/7tm3) | Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-01-19 | Release date: | 2022-10-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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7TUT
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![BU of 7tut by Molmil](/molmil-images/mine/7tut) | Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-02-03 | Release date: | 2022-10-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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4IP3
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![BU of 4ip3 by Molmil](/molmil-images/mine/4ip3) | Complex structure of OspI and Ubc13 | Descriptor: | ORF169b, Ubiquitin-conjugating enzyme E2 N | Authors: | Fu, P, Jin, M, Zhang, X, Xu, L, Xia, Z, Zhu, Y. | Deposit date: | 2013-01-09 | Release date: | 2013-03-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure Analysis of Ubc13 Inactivation To be Published
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1KI1
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![BU of 1ki1 by Molmil](/molmil-images/mine/1ki1) | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | Descriptor: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | Authors: | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | Deposit date: | 2001-12-02 | Release date: | 2002-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
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5WYJ
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![BU of 5wyj by Molmil](/molmil-images/mine/5wyj) | Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 40S ribosomal protein S1-A, ... | Authors: | Ye, K, Zhu, X, Sun, Q. | Deposit date: | 2017-01-13 | Release date: | 2017-03-29 | Last modified: | 2019-10-09 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | Molecular architecture of the 90S small subunit pre-ribosome. Elife, 6, 2017
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5C9Z
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5EMM
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5VYC
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![BU of 5vyc by Molmil](/molmil-images/mine/5vyc) | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Lomakin, I.B, Stolboushkina, E.A, Vaidya, A.T, Garber, M.B, Dmitriev, S.E, Steitz, T.A. | Deposit date: | 2017-05-24 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1. Cell Rep, 20, 2017
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5F6W
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![BU of 5f6w by Molmil](/molmil-images/mine/5f6w) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) | Descriptor: | 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6D
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![BU of 5f6d by Molmil](/molmil-images/mine/5f6d) | Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 | Descriptor: | 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-05 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.553 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6V
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![BU of 5f6v by Molmil](/molmil-images/mine/5f6v) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol from fragment cocktail screen) | Descriptor: | 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.492 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6X
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![BU of 5f6x by Molmil](/molmil-images/mine/5f6x) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6U
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![BU of 5f6u by Molmil](/molmil-images/mine/5f6u) | Crystal Structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 8 (JSS190B146) | Descriptor: | SUMO-conjugating enzyme UBC9, ethyl 3-[4-(2-hydroxyphenyl)-3-oxidanyl-phenyl]propanoate | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, Z, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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5F6Y
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![BU of 5f6y by Molmil](/molmil-images/mine/5f6y) | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole) | Descriptor: | 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 | Authors: | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | Deposit date: | 2015-12-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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4LNK
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![BU of 4lnk by Molmil](/molmil-images/mine/4lnk) | B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of GS-glutamate-AMPPCP complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Glutamine synthetase, ... | Authors: | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | Deposit date: | 2013-07-11 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism. J.Biol.Chem., 288, 2013
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4LNN
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![BU of 4lnn by Molmil](/molmil-images/mine/4lnn) | B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of apo form of GS | Descriptor: | Glutamine synthetase, MAGNESIUM ION, SULFATE ION | Authors: | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | Deposit date: | 2013-07-11 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism. J.Biol.Chem., 288, 2013
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4LNI
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![BU of 4lni by Molmil](/molmil-images/mine/4lni) | B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of the transition state complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ... | Authors: | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | Deposit date: | 2013-07-11 | Release date: | 2013-11-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5793 Å) | Cite: | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism. J.Biol.Chem., 288, 2013
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3CMM
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![BU of 3cmm by Molmil](/molmil-images/mine/3cmm) | Crystal Structure of the Uba1-Ubiquitin Complex | Descriptor: | PROLINE, Ubiquitin, Ubiquitin-activating enzyme E1 1 | Authors: | Lee, I, Schindelin, H. | Deposit date: | 2008-03-23 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes. Cell(Cambridge,Mass.), 134, 2008
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8S4G
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![BU of 8s4g by Molmil](/molmil-images/mine/8s4g) | Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2024-02-21 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex To Be Published
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5UQ3
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![BU of 5uq3 by Molmil](/molmil-images/mine/5uq3) | |