5F6V
Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol from fragment cocktail screen)
Summary for 5F6V
Entry DOI | 10.2210/pdb5f6v/pdb |
Related | 5F6D 5F6E 5F6U 5F6W 5F6X 5F6Y |
Descriptor | SUMO-conjugating enzyme UBC9, 2-(2-hydroxyphenyl)phenol (3 entities in total) |
Functional Keywords | ubc9, fragment drug design, sumoylation, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P63279 |
Total number of polymer chains | 1 |
Total formula weight | 17911.58 |
Authors | Lountos, G.T.,Hewitt, W.M.,Zlotkowski, K.,Dahlhauser, S.,Saunders, L.B.,Needle, D.,Tropea, J.E.,Zhan, C.,Wei, G.,Ma, B.,Nussinov, R.,Schneekloth, J.S.Jr.,Waugh, D.S. (deposition date: 2015-12-07, release date: 2016-04-27, Last modification date: 2023-09-27) |
Primary citation | Hewitt, W.M.,Lountos, G.T.,Zlotkowski, K.,Dahlhauser, S.D.,Saunders, L.B.,Needle, D.,Tropea, J.E.,Zhan, C.,Wei, G.,Ma, B.,Nussinov, R.,Waugh, D.S.,Schneekloth, J.S. Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55:5703-5707, 2016 Cited by PubMed: 27038327DOI: 10.1002/anie.201511351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.492 Å) |
Structure validation
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