7VYL
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7VYK
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7VYM
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7VXZ
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7ST5
| Structure of Fab CC-95251 in complex with SIRP-alpha | Descriptor: | 1,2-ETHANEDIOL, Fab CC-95251 anti-SIRP-alpha heavy chain, Fab CC-95251 anti-SIRP-alpha light chain, ... | Authors: | Fenalti, G. | Deposit date: | 2021-11-12 | Release date: | 2023-05-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRP alpha That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies. Cancer Res Commun, 4, 2024
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7VUX
| Complex structure of PD1 and 609A-Fab | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Huang, H, Zhu, Z, Zhao, J, Jiang, L, Yang, H, Deng, L, Meng, X, Ding, J, Yang, S, Zhao, L, Xu, W, Wang, X. | Deposit date: | 2021-11-04 | Release date: | 2021-11-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties. Mabs, 14, 2022
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7VUN
| Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction | Descriptor: | (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid, Programmed cell death 1 ligand 1 | Authors: | Cheng, Y, Sun, C.L, Chen, M.R, Yang, P, Xiao, Y.B. | Deposit date: | 2021-11-03 | Release date: | 2022-09-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents. Acta Pharm Sin B, 12, 2022
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7SJQ
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7RYN
| CD1a-sulfatide-gdTCR complex | Descriptor: | (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wegrecki, M, Le Nours, J, Rossjohn, J. | Deposit date: | 2021-08-25 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors. Nat Commun, 13, 2022
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7RYL
| T cell receptor CO3 | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, T cell receptor delta variable 1,T cell receptor alpha chain constant, ... | Authors: | Wegrecki, M, Le Nours, J, Rossjohn, J. | Deposit date: | 2021-08-25 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors. Nat Commun, 13, 2022
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7RYO
| CD1a-dideoxymycobactin-gdTCR complex | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, SULFATE ION, ... | Authors: | Wegrecki, M, Le Nours, J, Rossjohn, J. | Deposit date: | 2021-08-25 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors. Nat Commun, 13, 2022
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7RYM
| CD1a-endo-gdTCR complex | Descriptor: | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | Authors: | Wegrecki, M, Le Nours, J, Rossjohn, J. | Deposit date: | 2021-08-25 | Release date: | 2022-05-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors. Nat Commun, 13, 2022
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7RPP
| Crystal structure of human CEACAM1 with GFCC' and ABED face | Descriptor: | 1,2-ETHANEDIOL, Carcinoembryonic antigen-related cell adhesion molecule 1 | Authors: | Gandhi, A.K, Kim, W.M, Sun, Z.-Y, Huang, Y.H, Petsko, G.A, Blumberg, R.S. | Deposit date: | 2021-08-04 | Release date: | 2022-08-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural analysis of human CEACAM1 oligomerization. Commun Biol, 5, 2022
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7FJD
| Cryo-EM structure of a membrane protein(WT) | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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7FJF
| Cryo-EM structure of a membrane protein(CS) | Descriptor: | CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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7FJE
| Cryo-EM structure of a membrane protein(LL) | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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7RNO
| Model of the Ac-6-FP/hpMR1/bB2m/TAPBPR complex from integrated docking, NMR and restrained MD | Descriptor: | Beta-2-microglobulin, Major histocompatibility complex class I-related gene protein, N-(6-formyl-4-oxo-3,4-dihydropteridin-2-yl)acetamide, ... | Authors: | McShan, A.C, Sgourakis, N.G. | Deposit date: | 2021-07-29 | Release date: | 2022-05-11 | Last modified: | 2022-08-10 | Method: | SOLUTION NMR | Cite: | TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nat.Chem.Biol., 18, 2022
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7RBU
| SARS-CoV-2 Spike in complex with PVI.V6-14 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PVI.V6-14 Fab heavy chain, ... | Authors: | Altomare, C.G, Bajic, G. | Deposit date: | 2021-07-06 | Release date: | 2022-05-04 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain. Mbio, 13, 2022
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7OUN
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7N5P
| 6218 TCR in complex with H2-Db PA224-233 with a cysteine mutant | Descriptor: | Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... | Authors: | Szeto, C, Gras, S. | Deposit date: | 2021-06-06 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
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7N5C
| 6218 TCR in complex with H2Db PA with an engineered TCR-pMHC disulfide bond | Descriptor: | Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 with T-cell receptor, sp3.4 alpha chain, ... | Authors: | Szeto, C, Gras, S. | Deposit date: | 2021-06-05 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
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7N4K
| 6218 TCR in complex with H2-Db PA 224 | Descriptor: | Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... | Authors: | Szeto, C, Gras, S. | Deposit date: | 2021-06-04 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
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7MU8
| Structure of the minimally glycosylated human CEACAM1 N-terminal domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, ... | Authors: | Belcher Dufrisne, M, Swope, N, Kieber, M, Yang, J.Y, Han, J, Li, J, Moremen, K.W, Prestegard, J.H, Columbus, L. | Deposit date: | 2021-05-14 | Release date: | 2022-02-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Human CEACAM1 N-domain dimerization is independent from glycan modifications. Structure, 30, 2022
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7EO0
| FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY C4 | Descriptor: | Ig heavy chain variable region, Ig lamda chain variable region, O/TIBET/99 VP1, ... | Authors: | He, Y, Li, K. | Deposit date: | 2021-04-21 | Release date: | 2021-08-18 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Two Cross-Protective Antigen Sites on Foot-and-Mouth Disease Virus Serotype O Structurally Revealed by Broadly Neutralizing Antibodies from Cattle. J.Virol., 95, 2021
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7ELX
| The crystal structure of CTLA-4 and Fab | Descriptor: | Cytotoxic T-lymphocyte protein 4, heavy chain of Fab, light chain of Fab | Authors: | Yu, X.J, Wang, L, Yu, C.F. | Deposit date: | 2021-04-12 | Release date: | 2021-06-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | The crystal structure of CTLA-4 and Fab To Be Published
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