7SJQ

Ex silico engineering of cystine-dense peptides yielding a potent bispecific T-cell engager

Summary for 7SJQ

Entry DOI	10.2210/pdb7sjq/pdb
Descriptor	Programmed cell death 1 ligand 1, Cystine-dense peptide, GLYCEROL, ... (7 entities in total)
Functional Keywords	pdl1 binder, antitumor protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	19642.37
Authors	Rupert, P.B.,Strong, R. (deposition date: 2021-10-18, release date: 2022-06-08, Last modification date: 2023-10-18)
Primary citation	Crook, Z.R.,Girard, E.J.,Sevilla, G.P.,Brusniak, M.Y.,Rupert, P.B.,Friend, D.J.,Gewe, M.M.,Clarke, M.,Lin, I.,Ruff, R.,Pakiam, F.,Phi, T.D.,Bandaranayake, A.,Correnti, C.E.,Mhyre, A.J.,Nairn, N.W.,Strong, R.K.,Olson, J.M. Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager. Sci Transl Med, 14:eabn0402-eabn0402, 2022 Cited by PubMed: 35584229 DOI: 10.1126/scitranslmed.abn0402 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation