7SJQ
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T-cell engager
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Programmed cell death 1 ligand 1 | polymer | 119 | 13538.5 | 1 | UniProt (Q9NZQ7) Pfam (PF07686) | Homo sapiens (Human) | PD-L1,PDCD1 ligand 1,Programmed death ligand 1,hPD-L1,B7 homolog 1,B7-H1 |
| 2 | B (D) | Cystine-dense peptide | polymer | 51 | 5671.5 | 1 | synthetic construct | ||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | G, H (A, D) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 18 - 134 (UniProt: Q9NZQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19210.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 432.4 | |
| All* | Total formula weight | 19642.4 |
