7ST5

Structure of Fab CC-95251 in complex with SIRP-alpha

Summary for 7ST5

• Entry DOI: 10.2210/pdb7st5/pdb
• Descriptor: Fab CC-95251 anti-SIRP-alpha heavy chain, Fab CC-95251 anti-SIRP-alpha light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (6 entities in total)
• Functional Keywords: cell surface receptor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 122338.78

Authors

Fenalti, G. (deposition date: 2021-11-12, release date: 2023-05-17, Last modification date: 2023-10-25)

• Primary citation: Fenalti, G.; Discovery and preclinical activity of CC-95251, a SIRP-alpha antibody mediating tumor cell phagocytosis, in combination with target therapies; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)