7ST5
Structure of Fab CC-95251 in complex with SIRP-alpha
Summary for 7ST5
Entry DOI | 10.2210/pdb7st5/pdb |
Descriptor | Fab CC-95251 anti-SIRP-alpha heavy chain, Fab CC-95251 anti-SIRP-alpha light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (6 entities in total) |
Functional Keywords | cell surface receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 122338.78 |
Authors | Fenalti, G. (deposition date: 2021-11-12, release date: 2023-05-17, Last modification date: 2024-05-29) |
Primary citation | Chan, H.,Trout, C.V.,Mikolon, D.,Adams, P.,Guzman, R.,Mavrommatis, K.,Abbasian, M.,Hadjivassiliou, H.,Dearth, L.,Fox, B.A.,Sivakumar, P.,Cho, H.,Hariharan, K. Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRP alpha That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies. Cancer Res Commun, 4:505-515, 2024 Cited by PubMed: 38319147DOI: 10.1158/2767-9764.CRC-23-0634 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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