7ST5
Structure of Fab CC-95251 in complex with SIRP-alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (H, h) | Fab CC-95251 anti-SIRP-alpha heavy chain | polymer | 227 | 24223.1 | 2 | Homo sapiens (Human) | ||
| 2 | B, E (L, l) | Fab CC-95251 anti-SIRP-alpha light chain | polymer | 214 | 23115.7 | 2 | Homo sapiens (Human) | ||
| 3 | C, F (F, A) | Tyrosine-protein phosphatase non-receptor type substrate 1 | polymer | 125 | 13598.4 | 2 | UniProt (P78324) Pfam (PF07686) | Homo sapiens (Human) | SHP substrate 1,SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84 |
| 4 | G, I, J, K, L... (H, F, l, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | H (L) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | N, O, P, Q, R... (H, L, F, h, l...) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
F, A: 1 - 119 (UniProt: P78324)
| PDB | External Database | Details |
|---|---|---|
| Ser 120 | - | expression tag |
| Gly 121 | - | expression tag |
| Leu 122 | - | expression tag |
| Val 123 | - | expression tag |
| Pro 124 | - | expression tag |
| Arg 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 121874.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 464.5 | |
| All* | Total formula weight | 122338.8 |
