7OUN

Structure of human PD-L1 in complex with macrocyclic inhibitor

Summary for 7OUN

• Entry DOI: 10.2210/pdb7oun/pdb
• Descriptor: Programmed cell death 1 ligand 1, macrocyclic peptide (3 entities in total)
• Functional Keywords: programmed death ligand 1, immune checkpoint inhibitor, cancer, cell cycle, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 16494.92

Authors

Zyla, E.,Dubin, G. (deposition date: 2021-06-12, release date: 2021-09-15, Last modification date: 2024-01-31)

• Primary citation: Zyla, E.,Musielak, B.,Holak, T.A.,Dubin, G.; Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis.; Molecules, 26:-, 2021; PubMed: 34443436; DOI: 10.3390/molecules26164848

Experimental method

X-RAY DIFFRACTION (1.9 Å)