3Q7V
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3QLD
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![BU of 3qld by Molmil](/molmil-images/mine/3qld) | |
3Q9C
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3QB1
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![BU of 3qb1 by Molmil](/molmil-images/mine/3qb1) | Interleukin-2 mutant D10 | Descriptor: | Interleukin-2 | Authors: | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Fathman, C.G, Garcia, K.C. | Deposit date: | 2011-01-12 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
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3QNZ
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![BU of 3qnz by Molmil](/molmil-images/mine/3qnz) | Orthorhombic form of IgG1 Fab fragment (in complex with antigenic tubulin peptide) sharing same Fv as IgA | Descriptor: | Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN, Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN, GLYCEROL, ... | Authors: | Trajtenberg, F, Correa, A, Buschiazzo, A. | Deposit date: | 2011-02-09 | Release date: | 2012-02-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of a human IgA1 Fab fragment at 1.55 angstrom resolution: potential effect of the constant domains on antigen-affinity modulation Acta Crystallogr.,Sect.D, 69, 2013
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3QO6
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![BU of 3qo6 by Molmil](/molmil-images/mine/3qo6) | Crystal structure analysis of the plant protease Deg1 | Descriptor: | Protease Do-like 1, chloroplastic, peptide | Authors: | Clausen, T. | Deposit date: | 2011-02-09 | Release date: | 2011-05-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Nat.Struct.Mol.Biol., 18, 2011
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3QCJ
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3QPP
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![BU of 3qpp by Molmil](/molmil-images/mine/3qpp) | Structure of PDE10-inhibitor complex | Descriptor: | 7-methoxy-4-[(3S)-3-phenylpiperidin-1-yl]-6-[2-(quinolin-2-yl)ethoxy]quinazoline, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | Authors: | Pandit, J, Marr, E.S. | Deposit date: | 2011-02-14 | Release date: | 2011-06-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia. J.Med.Chem., 54, 2011
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3QQ8
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3QDG
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3Q5S
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![BU of 3q5s by Molmil](/molmil-images/mine/3q5s) | Crystal structure of BmrR bound to Acetylcholine | Descriptor: | 23 bp promoter DNA, ACETYLCHOLINE, GLYCEROL, ... | Authors: | Bachas, S, Eginton, C, Gunio, G, Wade, H. | Deposit date: | 2010-12-29 | Release date: | 2011-06-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Proc.Natl.Acad.Sci.USA, 108, 2011
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3Q7I
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![BU of 3q7i by Molmil](/molmil-images/mine/3q7i) | Glucose-6-phosphate isomerase from Francisella tularensis complexed with 6-phosphogluconic acid. | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-PHOSPHOGLUCONIC ACID, CALCIUM ION, ... | Authors: | Osipiuk, J, Maltseva, N, Hasseman, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-01-04 | Release date: | 2011-02-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Glucose-6-phosphate isomerase from Francisella tularensis. To be Published
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3Q8H
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![BU of 3q8h by Molmil](/molmil-images/mine/3q8h) | Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028 | Descriptor: | 1,2-ETHANEDIOL, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 5'-deoxy-5'-[(imidazo[2,1-b][1,3]thiazol-5-ylcarbonyl)amino]cytidine, ... | Authors: | Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2011-01-06 | Release date: | 2011-01-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg.Med.Chem.Lett., 23, 2013
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3QGD
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![BU of 3qgd by Molmil](/molmil-images/mine/3qgd) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)piperazine-2-carboxamide | Descriptor: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)piperazine-2-carboxamide, RNA-directed RNA polymerase, ... | Authors: | Sheriff, S. | Deposit date: | 2011-01-24 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 21, 2011
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3QAH
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![BU of 3qah by Molmil](/molmil-images/mine/3qah) | Crystal structure of apo-form human MOF catalytic domain | Descriptor: | Probable histone acetyltransferase MYST1, ZINC ION | Authors: | Sun, B, Tang, Q, Zhong, C, Ding, J. | Deposit date: | 2011-01-11 | Release date: | 2011-07-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274 Cell Res., 21, 2011
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3QCB
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![BU of 3qcb by Molmil](/molmil-images/mine/3qcb) | Human receptor protein tyrosine phosphatase gamma, domain 1, apo | Descriptor: | Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION | Authors: | Sheriff, S. | Deposit date: | 2011-01-16 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
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3QHD
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3QHW
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![BU of 3qhw by Molmil](/molmil-images/mine/3qhw) | Structure of a pCDK2/CyclinA transition-state mimic | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ... | Authors: | Young, M.A, Jacobsen, D.M, Bao, Z.Q. | Deposit date: | 2011-01-26 | Release date: | 2011-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
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3QD0
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![BU of 3qd0 by Molmil](/molmil-images/mine/3qd0) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide | Descriptor: | (3S,6R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ... | Authors: | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | Deposit date: | 2011-01-17 | Release date: | 2011-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3QDL
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![BU of 3qdl by Molmil](/molmil-images/mine/3qdl) | Crystal structure of RdxA from Helicobacter pyroli | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Oxygen-insensitive NADPH nitroreductase | Authors: | Rojas, A.L, Martinez-Julvez, M, Olekhnovich, I.N, Hoffman, P.S, Sancho, J. | Deposit date: | 2011-01-18 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori. Febs J., 279, 2012
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3QIU
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![BU of 3qiu by Molmil](/molmil-images/mine/3qiu) | Crystal structure of the 226 TCR in complex with MCC/I-Ek | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, E-K alpha chain, ... | Authors: | Kruse, A.C, Ely, L.K, Newell, E.W, Davis, M.M, Garcia, K.C. | Deposit date: | 2011-01-27 | Release date: | 2011-04-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). J.Immunol., 186, 2011
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3QJA
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3QKX
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3QGJ
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![BU of 3qgj by Molmil](/molmil-images/mine/3qgj) | 1.3A Structure of alpha-Lytic Protease Bound to Ac-AlaAlaPro-Alanal | Descriptor: | 1,2-ETHANEDIOL, Ac-AlaAlaPro-Alanal peptide, Alpha-lytic protease, ... | Authors: | Everill, P, Meinke, G, Bohm, A, Bachovchin, W. | Deposit date: | 2011-01-24 | Release date: | 2012-02-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Substrate Binding Defines Ser195 Position in the Catalytic Triad of Serine Proteases, Not His57 protonation To be Published
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3R0R
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![BU of 3r0r by Molmil](/molmil-images/mine/3r0r) | |