3Q8H

Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028

Summary for 3Q8H

Entry DOI	10.2210/pdb3q8h/pdb
Related	3f0d 3ieq 3ike 3ikf 3jvh 3k14 3ke1 3mbm 3p0z
Descriptor	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-deoxy-5'-[(imidazo[2,1-b][1,3]thiazol-5-ylcarbonyl)amino]cytidine, ... (6 entities in total)
Functional Keywords	seattle structural genomics center for infectious disease, ssgcid, ispf, mep pathway, lyase, metal-binding, isoprene biosynthesis
Biological source	Burkholderia pseudomallei (Pseudomonas pseudomallei)
Total number of polymer chains	3
Total formula weight	59997.96
Authors	Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2011-01-06, release date: 2011-01-19, Last modification date: 2023-09-13)
Primary citation	Zhang, Z.,Jakkaraju, S.,Blain, J.,Gogol, K.,Zhao, L.,Hartley, R.C.,Karlsson, C.A.,Staker, B.L.,Edwards, T.E.,Stewart, L.J.,Myler, P.J.,Clare, M.,Begley, D.W.,Horn, J.R.,Hagen, T.J. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg.Med.Chem.Lett., 23:6860-6863, 2013 Cited by PubMed: 24157367 DOI: 10.1016/j.bmcl.2013.09.101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation