7PG0
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![BU of 7pg0 by Molmil](/molmil-images/mine/7pg0) | Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1 | Descriptor: | Insulin, Isoform Short of Insulin receptor | Authors: | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | Deposit date: | 2021-08-12 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7PG4
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![BU of 7pg4 by Molmil](/molmil-images/mine/7pg4) | Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3 | Descriptor: | Insulin, Isoform Short of Insulin receptor | Authors: | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | Deposit date: | 2021-08-12 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7PG3
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![BU of 7pg3 by Molmil](/molmil-images/mine/7pg3) | Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2 | Descriptor: | Insulin, Isoform Short of Insulin receptor | Authors: | Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. | Deposit date: | 2021-08-12 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
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7F7Q
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![BU of 7f7q by Molmil](/molmil-images/mine/7f7q) | |
7F7R
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![BU of 7f7r by Molmil](/molmil-images/mine/7f7r) | |
7OPB
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![BU of 7opb by Molmil](/molmil-images/mine/7opb) | IL7R in complex with an antagonist | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ... | Authors: | Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N. | Deposit date: | 2021-05-31 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.144 Å) | Cite: | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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7MRS
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![BU of 7mrs by Molmil](/molmil-images/mine/7mrs) | Zebrafish CNTN4 APPb complex | Descriptor: | Amyloid-beta A4 protein, Contactin-4 | Authors: | Bouyain, S, Karuppan, S.J. | Deposit date: | 2021-05-09 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. J.Biol.Chem., 298, 2021
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7MQY
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![BU of 7mqy by Molmil](/molmil-images/mine/7mqy) | Zebrafish CNTN4 APLP2 complex | Descriptor: | Fusion protein of CNTN4 and APLP2 | Authors: | Bouyain, S, Karuppan, S.J. | Deposit date: | 2021-05-07 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. J.Biol.Chem., 298, 2021
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7MRO
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![BU of 7mro by Molmil](/molmil-images/mine/7mro) | Zebrafish CNTN4 FN1-FN3 domains | Descriptor: | Contactin-4 | Authors: | Bouyain, S, Karuppan, S.J. | Deposit date: | 2021-05-07 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. J.Biol.Chem., 298, 2021
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7MRN
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![BU of 7mrn by Molmil](/molmil-images/mine/7mrn) | Mouse CNTN5 APP complex | Descriptor: | Contactin-5, N-APP | Authors: | Bouyain, S, Karuppan, S.J. | Deposit date: | 2021-05-07 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. J.Biol.Chem., 298, 2021
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7MQS
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![BU of 7mqs by Molmil](/molmil-images/mine/7mqs) | The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation | Descriptor: | Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | Deposit date: | 2021-05-06 | Release date: | 2022-03-16 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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7MQO
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![BU of 7mqo by Molmil](/molmil-images/mine/7mqo) | The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, ... | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | Deposit date: | 2021-05-06 | Release date: | 2022-03-16 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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7MQR
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![BU of 7mqr by Molmil](/molmil-images/mine/7mqr) | The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | Deposit date: | 2021-05-06 | Release date: | 2022-03-16 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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7MD4
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![BU of 7md4 by Molmil](/molmil-images/mine/7md4) | Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists | Descriptor: | Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ... | Authors: | Gomez-Llorente, Y, Zhou, H, Scapin, G. | Deposit date: | 2021-04-03 | Release date: | 2022-02-23 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7MD5
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![BU of 7md5 by Molmil](/molmil-images/mine/7md5) | Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gomez-Llorente, Y, Zhou, H, Scapin, G. | Deposit date: | 2021-04-03 | Release date: | 2022-02-23 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7NWL
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![BU of 7nwl by Molmil](/molmil-images/mine/7nwl) | Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-17 | Release date: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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7E72
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![BU of 7e72 by Molmil](/molmil-images/mine/7e72) | Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3 | Descriptor: | 1,2-ETHANEDIOL, Angiopoietin-1 receptor, the chimeric Fab fragment of 3H7 (heavy chain), ... | Authors: | Kim, H.M, Jo, G.H, Hong, H.J, Han, A. | Deposit date: | 2021-02-25 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.094 Å) | Cite: | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody. Nat Commun, 12, 2021
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7NE1
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![BU of 7ne1 by Molmil](/molmil-images/mine/7ne1) | Structure of the complex between Netrin-1 and its receptor Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE0
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![BU of 7ne0 by Molmil](/molmil-images/mine/7ne0) | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NDG
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![BU of 7ndg by Molmil](/molmil-images/mine/7ndg) | Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-01 | Release date: | 2021-03-31 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (5.98 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7K7J
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![BU of 7k7j by Molmil](/molmil-images/mine/7k7j) | EphB6 receptor ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 6 | Authors: | Goldgur, Y, Himanen, J. | Deposit date: | 2020-09-22 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Structure of the EphB6 receptor ectodomain. Plos One, 16, 2021
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6ZZ8
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![BU of 6zz8 by Molmil](/molmil-images/mine/6zz8) | MB_CRS6-15 bound to CrSAS-6_6HR | Descriptor: | Centriole protein, Protein B | Authors: | Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P. | Deposit date: | 2020-08-04 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.73 Å) | Cite: | Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly. Nat Commun, 12, 2021
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6ZVA
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![BU of 6zva by Molmil](/molmil-images/mine/6zva) | Crystal structure of My5 | Descriptor: | Myomesin-1, SULFATE ION | Authors: | Sauer, F, Wilmanns, M. | Deposit date: | 2020-07-24 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Crystal structure of Myomesin-1 To Be Published
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7JGT
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![BU of 7jgt by Molmil](/molmil-images/mine/7jgt) | Crystal Structure of FN3tt | Descriptor: | Fibronectin type-III domain-containing protein | Authors: | Luo, J, Malia, T.J. | Deposit date: | 2020-07-19 | Release date: | 2021-07-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Surface salt bridges contribute to the extreme thermal stability of an FN3-like domain from a thermophilic bacterium. Proteins, 90, 2022
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7JGU
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![BU of 7jgu by Molmil](/molmil-images/mine/7jgu) | Structure of FN3tt mut | Descriptor: | Fibronectin type-III domain-containing protein, PENTAETHYLENE GLYCOL | Authors: | Luo, J, Boucher, L.E. | Deposit date: | 2020-07-19 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Surface salt bridges contribute to the extreme thermal stability of an FN3-like domain from a thermophilic bacterium. Proteins, 90, 2022
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