7NDG

Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B

Summary for 7NDG

• Entry DOI: 10.2210/pdb7ndg/pdb
• EMDB information: 12286
• Descriptor: Netrin-1, Neogenin, Repulsive Guidance Molecule B (C-terminal region), ... (6 entities in total)
• Functional Keywords: signal transduction, cell surface receptors, neuron regeneration, cell migration, netrin, neogenin, repulsive guidance molecule, complex structure, protein-protein interactions, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 391642.15

Authors

Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. (deposition date: 2021-02-01, release date: 2021-03-31, Last modification date: 2021-04-28)

• Primary citation: Robinson, R.A.,Griffiths, S.C.,van de Haar, L.L.,Malinauskas, T.,van Battum, E.Y.,Zelina, P.,Schwab, R.A.,Karia, D.,Malinauskaite, L.,Brignani, S.,van den Munkhof, M.H.,Dudukcu, O.,De Ruiter, A.A.,Van den Heuvel, D.M.A.,Bishop, B.,Elegheert, J.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C.; Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.; Cell, 184:2103-, 2021; PubMed: 33740419; DOI: 10.1016/j.cell.2021.02.045

Experimental method

ELECTRON MICROSCOPY (5.98 Å)