4ZUS
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![BU of 4zus by Molmil](/molmil-images/mine/4zus) | Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide REV-QW11 | Descriptor: | Beta-2-microglobulin, Classical MHC class I antigen, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP | Authors: | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | Deposit date: | 2015-05-17 | Release date: | 2016-04-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
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8SRB
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![BU of 8srb by Molmil](/molmil-images/mine/8srb) | Cryo-EM structure of TRPM2 chanzyme in the presence of EDTA and ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, TRPM2 chanzyme | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SQ8
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![BU of 8sq8 by Molmil](/molmil-images/mine/8sq8) | X-ray crystal structure of Acinetobacter baumanii beta-lactamase variant OXA-109 in complex with doripenem | Descriptor: | (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase OXA-109 | Authors: | Powers, R.A, Leonard, D.A, June, C.M, Szarecka, A, Wawrzak, Z. | Deposit date: | 2023-05-04 | Release date: | 2024-05-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural and Dynamic Features of Acinetobacter baumannii OXA-66 beta-Lactamase Explain Its Stability and Evolution of Novel Variants. J.Mol.Biol., 436, 2024
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8SUE
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![BU of 8sue by Molmil](/molmil-images/mine/8sue) | Human asparagine synthetase (apo-ASNS) | Descriptor: | Asparagine synthetase [glutamine-hydrolyzing] | Authors: | Coricello, A, Zhu, W, Lupia, A, Gratteri, C, Vos, M, Chaptal, V, Alcaro, S, Takagi, Y, Richards, N. | Deposit date: | 2023-05-12 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Human asparagine synthetase (apo-ASNS) To Be Published
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8SW8
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![BU of 8sw8 by Molmil](/molmil-images/mine/8sw8) | Crystal Structure of HaloTag7 bound to JF669-HaloTag ligand | Descriptor: | 1-[(4aM,10P)-7-(azetidin-1-yl)-10-[2-carboxy-3,4,6-trifluoro-5-({2-[2-(hexyloxy)ethoxy]ethyl}carbamoyl)phenyl]-5,5-dimethyldibenzo[b,e]silin-3(5H)-ylidene]azetidin-1-ium, CHLORIDE ION, Haloalkane dehalogenase | Authors: | Farrants, H, Schreiter, E.R. | Deposit date: | 2023-05-17 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A modular chemigenetic calcium indicator for multiplexed in vivo functional imaging To Be Published
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8T18
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8T14
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![BU of 8t14 by Molmil](/molmil-images/mine/8t14) | ADP-bound Bcs1 (C7 symmetrized) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Mitochondrial chaperone BCS1 | Authors: | Zhan, J, Xia, D. | Deposit date: | 2023-06-01 | Release date: | 2024-06-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate. Nat Commun, 15, 2024
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8T0S
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![BU of 8t0s by Molmil](/molmil-images/mine/8t0s) | Crystal structure of UBE2G2 adduct with phenethyl isothiocyanate (PEITC) at the Cys48 position | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase AMFR, Ubiquitin-conjugating enzyme E2 G2 | Authors: | Wang, C, Shaw, G.X, Shi, G, Ji, X. | Deposit date: | 2023-06-01 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of UBE2G2 adduct with phenethyl isothiocyanate (PEITC) at the Cys48 position To be published
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8T15
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![BU of 8t15 by Molmil](/molmil-images/mine/8t15) | |
8SZK
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![BU of 8szk by Molmil](/molmil-images/mine/8szk) | |
8T17
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![BU of 8t17 by Molmil](/molmil-images/mine/8t17) | |
8SSI
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![BU of 8ssi by Molmil](/molmil-images/mine/8ssi) | |
8SV7
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![BU of 8sv7 by Molmil](/molmil-images/mine/8sv7) | |
8SLW
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![BU of 8slw by Molmil](/molmil-images/mine/8slw) | Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-4 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SLA
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![BU of 8sla by Molmil](/molmil-images/mine/8sla) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-2 | Descriptor: | Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SF4
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8S1R
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8S3R
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![BU of 8s3r by Molmil](/molmil-images/mine/8s3r) | HUMAN PI3KDELTA IN COMPLEX WITH PYRIDAZINONE INHIBITOR 7 | Descriptor: | 5-[(1~{S})-1-[4-azanyl-3-(5-oxidanylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-cyclopentyl-2-(phenylmethyl)pyridazin-3-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Authors: | Pala, D, Bruno, P, Capelli, A.M, Biagetti, M. | Deposit date: | 2024-02-20 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Discovery and Optimization of Pyridazinones as PI3K delta Selective Inhibitors for Administration by Inhalation. J.Med.Chem., 67, 2024
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8SLE
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![BU of 8sle by Molmil](/molmil-images/mine/8sle) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-3 | Descriptor: | Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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5AJ3
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![BU of 5aj3 by Molmil](/molmil-images/mine/5aj3) | Structure of the small subunit of the mammalian mitoribosome | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MITORIBOSOMAL 12S RRNA, ... | Authors: | Greber, B.J, Bieri, P, Leibundgut, M, Leitner, A, Aebersold, R, Boehringer, D, Ban, N. | Deposit date: | 2015-02-20 | Release date: | 2015-04-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome. Science, 348, 2015
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8SL8
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![BU of 8sl8 by Molmil](/molmil-images/mine/8sl8) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-1 | Descriptor: | Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SLP
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![BU of 8slp by Molmil](/molmil-images/mine/8slp) | Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-2 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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5AJ9
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![BU of 5aj9 by Molmil](/molmil-images/mine/5aj9) | G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARYLSULFATASE, CALCIUM ION, ... | Authors: | Miton, C.M, Fischer, G, Jonas, S, Mohammed, M.F, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | Deposit date: | 2015-02-20 | Release date: | 2016-03-16 | Last modified: | 2019-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8SP4
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![BU of 8sp4 by Molmil](/molmil-images/mine/8sp4) | |
8T0Q
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![BU of 8t0q by Molmil](/molmil-images/mine/8t0q) | Open state of lysine 5,6-aminomutase from Thermoanaerobacter tengcongensis | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, D-lysine 5,6-aminomutase alpha subunit, ... | Authors: | Tian, S, Voss, P, Pham, K, Klose, T. | Deposit date: | 2023-06-01 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Catalysis in Motion: Large-Scale Domain Shift Enables Co-C Bond Homolysis in Lysine 5,6-Aminomutase To Be Published
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