7L0R
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![BU of 7l0r by Molmil](/molmil-images/mine/7l0r) | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, without AHD | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | Deposit date: | 2020-12-12 | Release date: | 2021-01-06 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021
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6UP7
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![BU of 6up7 by Molmil](/molmil-images/mine/6up7) | neurotensin receptor and arrestin2 complex | Descriptor: | ARG-ARG-PRO-TYR-ILE-LEU, Beta-arrestin-1, Neurotensin receptor type 1, ... | Authors: | Qu, Q.H, Huang, W, Masureel, M, Janetzko, J, Kobilka, B.K, Skiniotis, G. | Deposit date: | 2019-10-16 | Release date: | 2020-02-26 | Last modified: | 2020-06-17 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the neurotensin receptor 1 in complex with beta-arrestin 1. Nature, 579, 2020
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7BB6
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![BU of 7bb6 by Molmil](/molmil-images/mine/7bb6) | AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Bous, J, Mouillac, B, Bron, P, Granier, S, Floquet, N, Leyrat, C. | Deposit date: | 2020-12-17 | Release date: | 2021-06-02 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex. Sci Adv, 7, 2021
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8GEJ
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![BU of 8gej by Molmil](/molmil-images/mine/8gej) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#20 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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6MH8
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![BU of 6mh8 by Molmil](/molmil-images/mine/6mh8) | High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct | Authors: | Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W. | Deposit date: | 2018-09-17 | Release date: | 2019-04-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. Iucrj, 6, 2019
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7W0N
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![BU of 7w0n by Molmil](/molmil-images/mine/7w0n) | Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | Descriptor: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | Deposit date: | 2021-11-18 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (4.21 Å) | Cite: | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8FD1
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![BU of 8fd1 by Molmil](/molmil-images/mine/8fd1) | Crystal structure of photoactivated rhodopsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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7L0Q
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![BU of 7l0q by Molmil](/molmil-images/mine/7l0q) | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, with AHD | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | Deposit date: | 2020-12-12 | Release date: | 2021-01-06 | Last modified: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021
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7FII
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![BU of 7fii by Molmil](/molmil-images/mine/7fii) | luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex | Descriptor: | Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, Glycoprotein hormones alpha chain, ... | Authors: | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | Deposit date: | 2021-07-31 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structures of full-length glycoprotein hormone receptor signalling complexes. Nature, 598, 2021
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6QNO
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![BU of 6qno by Molmil](/molmil-images/mine/6qno) | Rhodopsin-Gi protein complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab antibody fragment heavy chain, Fab antibody fragment light chain, ... | Authors: | Tsai, C.-J, Marino, J, Adaixo, R.J, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N.M.I, Mohammed, I, Matile, H, Dawson, R.J.P, Deupi, X, Stahlberg, H, Schertler, G.F.X. | Deposit date: | 2019-02-11 | Release date: | 2019-07-10 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.38 Å) | Cite: | Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit. Elife, 8, 2019
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7BB7
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![BU of 7bb7 by Molmil](/molmil-images/mine/7bb7) | AVP-V2R-Galphas-beta1-gamma2-Nb35(T state) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Bous, J, Mouillac, B, Bron, P, Granier, S, Floquet, N, Leyrat, C. | Deposit date: | 2020-12-17 | Release date: | 2021-06-02 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex. Sci Adv, 7, 2021
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7L0S
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![BU of 7l0s by Molmil](/molmil-images/mine/7l0s) | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhang, M, Gui, M, Wang, Z, Gorgulla, C, Yu, J.J, Wu, H, Sun, Z, Klenk, C, Merklinger, L, Morstein, L, Hagn, F, Pluckthun, A, Brown, A, Nasr, M.L, Wagner, G. | Deposit date: | 2020-12-12 | Release date: | 2021-01-06 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021
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6OFJ
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![BU of 6ofj by Molmil](/molmil-images/mine/6ofj) | |
6CMO
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![BU of 6cmo by Molmil](/molmil-images/mine/6cmo) | Rhodopsin-Gi complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | Authors: | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | Deposit date: | 2018-03-05 | Release date: | 2018-06-20 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
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7YU8
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![BU of 7yu8 by Molmil](/molmil-images/mine/7yu8) | Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Akasaka, H, Shihoya, W, Nureki, O. | Deposit date: | 2022-08-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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6MET
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![BU of 6met by Molmil](/molmil-images/mine/6met) | Structural basis of coreceptor recognition by HIV-1 envelope spike | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shaik, M.M, Chen, B. | Deposit date: | 2018-09-07 | Release date: | 2018-12-12 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature, 565, 2018
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7R0C
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![BU of 7r0c by Molmil](/molmil-images/mine/7r0c) | Structure of the AVP-V2R-arrestin2-ScFv30 complex | Descriptor: | AVP, Arrestin2, ScFv30, ... | Authors: | Bous, J, Fouillen, A, Trapani, S, Granier, S, Mouillac, B, Bron, P. | Deposit date: | 2022-02-01 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.73 Å) | Cite: | Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex. Sci Adv, 8, 2022
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6PWC
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![BU of 6pwc by Molmil](/molmil-images/mine/6pwc) | A complex structure of arrestin-2 bound to neurotensin receptor 1 | Descriptor: | Beta-arrestin-1, Fab30 heavy chain, Fab30 light chain, ... | Authors: | Yin, W, Li, Z, Jin, M, Yin, Y.-L, de Waal, P.W, Pal, K, Gao, X, He, Y, Gao, J, Wang, X, Zhang, Y, Zhou, H, Melcher, K, Jiang, Y, Cong, Y, Zhou, X.E, Yu, X, Xu, H.E. | Deposit date: | 2019-07-22 | Release date: | 2019-12-04 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Res., 29, 2019
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7XW7
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![BU of 7xw7 by Molmil](/molmil-images/mine/7xw7) | TSHR-K1-70 complex | Descriptor: | K1-70 scFv, Thyrotropin receptor | Authors: | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-05-26 | Release date: | 2022-08-17 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
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7MT8
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![BU of 7mt8 by Molmil](/molmil-images/mine/7mt8) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | Descriptor: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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8I2H
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![BU of 8i2h by Molmil](/molmil-images/mine/8i2h) | Follicle stimulating hormone receptor | Descriptor: | Follicle-stimulating hormone receptor | Authors: | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | Deposit date: | 2023-01-14 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
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7MT9
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![BU of 7mt9 by Molmil](/molmil-images/mine/7mt9) | Rhodopsin kinase (GRK1) in complex with rhodopsin | Descriptor: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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5DGY
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![BU of 5dgy by Molmil](/molmil-images/mine/5dgy) | Crystal structure of rhodopsin bound to visual arrestin | Descriptor: | Endolysin,Rhodopsin,S-arrestin | Authors: | Zhou, X.E, Gao, X, Kang, Y, He, Y, de Waal, P.W, Suino-Powell, K.M, Wang, M, Melcher, K, Xu, H.E. | Deposit date: | 2015-08-28 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (7.7 Å) | Cite: | X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Sci Data, 3, 2016
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2KS9
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![BU of 2ks9 by Molmil](/molmil-images/mine/2ks9) | |
2KSB
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![BU of 2ksb by Molmil](/molmil-images/mine/2ksb) | |