7UXH
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![BU of 7uxh by Molmil](/molmil-images/mine/7uxh) | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Cui, Z, Hurley, J. | Deposit date: | 2022-05-05 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
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7UXC
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3REP
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![BU of 3rep by Molmil](/molmil-images/mine/3rep) | |
5ITD
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![BU of 5itd by Molmil](/molmil-images/mine/5itd) | Crystal structure of PI3K alpha with PI3K delta inhibitor | Descriptor: | 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Elling, R.A. | Deposit date: | 2016-03-16 | Release date: | 2016-09-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. Acs Med.Chem.Lett., 7, 2016
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7OHH
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![BU of 7ohh by Molmil](/molmil-images/mine/7ohh) | SaFtsZ complexed with GDP and BeF3- | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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7OHK
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![BU of 7ohk by Molmil](/molmil-images/mine/7ohk) | SaFtsZ complexed with GDP, BeF3- and Mg2+ | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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7OI2
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![BU of 7oi2 by Molmil](/molmil-images/mine/7oi2) | SaFtsz complexed with GDP (NaCl purification) | Descriptor: | 1,2-ETHANEDIOL, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu Morales, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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7OHN
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![BU of 7ohn by Molmil](/molmil-images/mine/7ohn) | SaFtsZ complexed with GDP, AlF4- and Mg2+ | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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7OHL
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![BU of 7ohl by Molmil](/molmil-images/mine/7ohl) | SaFtsZ complexed with GDP, BeF3- and Mn2+ | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | Deposit date: | 2021-05-11 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics. Plos Biol., 20, 2022
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8TTT
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![BU of 8ttt by Molmil](/molmil-images/mine/8ttt) | Structure of SNX27 FERM complexed with Fam21A repeat 15 (1124-1140) | Descriptor: | DI(HYDROXYETHYL)ETHER, Fam21A repeat 15 peptide, GLYCEROL, ... | Authors: | Guo, Q, Chen, K.-E, Collins, B.M. | Deposit date: | 2023-08-15 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTV
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8TTU
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![BU of 8ttu by Molmil](/molmil-images/mine/8ttu) | Structure of SNX27 FERM complexed with Fam21A repeat 19 (1261 - 1274) | Descriptor: | DI(HYDROXYETHYL)ETHER, Fam21A repeat 19 peptide, GLYCEROL, ... | Authors: | Guo, Q, Chen, K.-E, Collins, B.M. | Deposit date: | 2023-08-15 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTD
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8TTA
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![BU of 8tta by Molmil](/molmil-images/mine/8tta) | Structure of retromer VPS29-VPS35 (483-796) complexed with Fam21A repeat 21 (1328-1341) | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | Deposit date: | 2023-08-13 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (3.46 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTC
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![BU of 8ttc by Molmil](/molmil-images/mine/8ttc) | Structure of retromer VPS29-VPS35 (483-796) complexed with Fam21A repeat 20 (1289-1302) | Descriptor: | ACETATE ION, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | Deposit date: | 2023-08-13 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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5JHH
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![BU of 5jhh by Molmil](/molmil-images/mine/5jhh) | Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11 | Descriptor: | 3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid, GLYCEROL, Rho guanine nucleotide exchange factor 11, ... | Authors: | Lv, Z, Wang, R, Ma, L, Miao, Q, Wu, J, Yan, Z, Li, J, Miao, L, Wang, F. | Deposit date: | 2016-04-21 | Release date: | 2017-04-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF To Be Published
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5JHG
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![BU of 5jhg by Molmil](/molmil-images/mine/5jhg) | Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | Descriptor: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | Authors: | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | Deposit date: | 2016-04-21 | Release date: | 2017-04-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11 To Be Published
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4KEE
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5JCP
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![BU of 5jcp by Molmil](/molmil-images/mine/5jcp) | RhoGAP domain of ARAP3 in complex with RhoA in the transition state | Descriptor: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3,Linker,Transforming protein RhoA, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Bao, H, Li, F, Wang, C, Wang, N, Jiang, Y, Tang, Y, Wu, J, Shi, Y. | Deposit date: | 2016-04-15 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem., 291, 2016
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5IRC
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![BU of 5irc by Molmil](/molmil-images/mine/5irc) | p190A GAP domain complex with RhoA | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Derewenda, U, Derewenda, Z. | Deposit date: | 2016-03-12 | Release date: | 2016-08-17 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. J.Biol.Chem., 291, 2016
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4KEF
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![BU of 4kef by Molmil](/molmil-images/mine/4kef) | |
4KED
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![BU of 4ked by Molmil](/molmil-images/mine/4ked) | |
5KY6
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8XEP
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![BU of 8xep by Molmil](/molmil-images/mine/8xep) | Crystal structure of a Legionella pneumophila type IV effector in complex with ubiquitin | Descriptor: | SULFATE ION, Type IV effector MavL, Ubiquitin | Authors: | Tan, J.X, Wang, X.F, Zhou, Y, Zhu, Y.Q. | Deposit date: | 2023-12-12 | Release date: | 2024-05-01 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
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7G84
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![BU of 7g84 by Molmil](/molmil-images/mine/7g84) | ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1102357527 | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, N-[(3R)-6-oxopiperidin-3-yl]-1,3-thiazole-4-carboxamide, ... | Authors: | Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. | Deposit date: | 2023-06-22 | Release date: | 2023-07-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | ARHGEF2 PanDDA analysis group deposition To Be Published
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