5ITD

Crystal structure of PI3K alpha with PI3K delta inhibitor

Summary for 5ITD

Entry DOI	10.2210/pdb5itd/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, ... (4 entities in total)
Functional Keywords	inhibitor, lipid kinase, pi3k, alpha, delta, transferase-protein transport-inhibitor complex, transferase/protein transport/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	164523.84
Authors	Knapp, M.S.,Elling, R.A. (deposition date: 2016-03-16, release date: 2016-09-07, Last modification date: 2024-04-03)
Primary citation	Hoegenauer, K.,Soldermann, N.,Stauffer, F.,Furet, P.,Graveleau, N.,Smith, A.B.,Hebach, C.,Hollingworth, G.J.,Lewis, I.,Gutmann, S.,Rummel, G.,Knapp, M.,Wolf, R.M.,Blanz, J.,Feifel, R.,Burkhart, C.,Zecri, F. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. Acs Med.Chem.Lett., 7:762-767, 2016 Cited by PubMed: 27563400 DOI: 10.1021/acsmedchemlett.6b00119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.02 Å)

Structure validation