PDB: 498 resultsInfo pagesStatus searchChemie searchBIRD

---

3UPN	Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Penicillin-binding protein A Authors: Davies, C, Fedorovich, A. Deposit date: 2011-11-18 Release date: 2012-10-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis J.Mol.Biol., 418, 2012
3UPP	Structure of penicillin-binding protein A from M. tuberculosis: ceftrixaone acyl-enzyme complex Descriptor: CEFOTAXIME, C3' cleaved, open, ... Authors: Davies, C, Fedorovich, A. Deposit date: 2011-11-18 Release date: 2012-10-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis J.Mol.Biol., 418, 2012
1Z6F	Crystal structure of penicillin-binding protein 5 from E. coli in complex with a boronic acid inhibitor Descriptor: GLYCEROL, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, Penicillin-binding protein 5 Authors: Nicola, G, Peddi, S, Stefanova, M, Nicholas, R.A, Gutheil, W.G, Davies, C. Deposit date: 2005-03-22 Release date: 2005-06-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation. Biochemistry, 44, 2005
3EQU	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION Authors: Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C. Deposit date: 2008-10-01 Release date: 2008-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance. J.Biol.Chem., 284, 2009
3VSK	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the apo form. Descriptor: Penicillin-binding protein 3 Authors: Yoshida, H, Tame, J.R, Park, S.Y. Deposit date: 2012-04-25 Release date: 2012-10-31 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
1NZU	Wild-type penicillin-binding protein 5 from E. coli modified by beta-mercaptoethanol Descriptor: BETA-MERCAPTOETHANOL, Penicillin-binding protein 5 Authors: Nicola, G, Nicholas, R.A, Davies, C. Deposit date: 2003-02-19 Release date: 2004-03-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli. Biochem.J., 392, 2005
1SDN	CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 MODIFIED BY MERCURY Descriptor: MERCURY (II) ION, Penicillin-binding protein 5 Authors: Nicola, G, Nicholas, R.A, Davies, C. Deposit date: 2004-02-13 Release date: 2005-02-22 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli. Biochem.J., 392, 2005
2ZC4	Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae Descriptor: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 2X, SULFATE ION Authors: Yamada, M, Watanabe, T, Takeuchi, Y. Deposit date: 2007-11-02 Release date: 2008-04-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC5	Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae Descriptor: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, Penicillin-binding protein 1A, ZINC ION Authors: Yamada, M, Watanabe, T, Takeuchi, Y. Deposit date: 2007-11-02 Release date: 2008-04-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC6	Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae Descriptor: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 1A, ZINC ION Authors: Yamada, M, Watanabe, T, Takeuchi, Y. Deposit date: 2007-11-02 Release date: 2008-04-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC3	Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae Descriptor: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, Penicillin-binding protein 2X, SULFATE ION Authors: Yamada, M, Watanabe, T, Takeuchi, Y. Deposit date: 2007-11-02 Release date: 2008-04-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
7O4C	Crystal structure of PASTA domains of the Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus Descriptor: CHLORIDE ION, Penicillin-binding protein 1 Authors: Martinez Caballero, S, Hermoso, J.A. Deposit date: 2021-04-05 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7O4A	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with piperacillin Descriptor: Hydrolyzed piperacillin, Penicillin-binding protein 1 Authors: Martinez Caballero, S, Hermoso, J.A. Deposit date: 2021-04-05 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.028 Å) Cite: Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7O49	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, CHLORIDE ION, ... Authors: Martinez Caballero, S, Hermoso, J.A. Deposit date: 2021-04-05 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.03 Å) Cite: Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
5CXW	Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V Descriptor: (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... Authors: Filippova, E.V, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) Deposit date: 2015-07-29 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283, 2016
7O4B	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with penicillin G Descriptor: CITRIC ACID, OPEN FORM - PENICILLIN G, Penicillin-binding protein 1, ... Authors: Martinez Caballero, S, Hermoso, J.A. Deposit date: 2021-04-05 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.593 Å) Cite: Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7OK9	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with pentaglycine Descriptor: CADMIUM ION, CHLORIDE ION, Penicillin-binding protein 1, ... Authors: Martinez Caballero, S, Hermoso, J.A. Deposit date: 2021-05-17 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.36 Å) Cite: Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
5KSH	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION Authors: Fedarovich, A, Davies, C. Deposit date: 2016-07-08 Release date: 2017-03-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry, 56, 2017
2BG1	Active site restructuring regulates ligand recognition in classA Penicillin-binding proteins (PBPs) Descriptor: CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, SULFATE ION Authors: Macheboeuf, P, Di Guilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. Deposit date: 2004-12-16 Release date: 2005-03-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins Proc.Natl.Acad.Sci.USA, 102, 2005
6MKI	Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the ceftaroline-bound form Descriptor: Ceftaroline, bound form, GLYCEROL, ... Authors: D'Andrea, E.D, Moon, T.M, Peti, W, Page, R. Deposit date: 2018-09-25 Release date: 2018-10-31 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.984 Å) Cite: The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
2UWX	Active site restructuring regulates ligand recognition in class A penicillin-binding proteins Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, ... Authors: Macheboeuf, P, DiGuilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. Deposit date: 2007-03-23 Release date: 2007-04-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins Proc.Natl.Acad.Sci.USA, 102, 2005
2XD1	ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS Descriptor: CEFOTAXIME, C3' cleaved, open, ... Authors: Macheboeuf, P, Di Guilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. Deposit date: 2010-04-28 Release date: 2010-05-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins. Proc.Natl.Acad.Sci.USA, 102, 2005
3VSL	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the cefotaxime bound form. Descriptor: CEFOTAXIME, C3' cleaved, open, ... Authors: Yoshida, H, Tame, J.R, Park, S.Y. Deposit date: 2012-04-25 Release date: 2012-10-31 Last modified: 2017-03-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
2Z2M	Cefditoren-Acylated Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae Descriptor: (2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-[(Z)-2-(4-METHYL-1,3-THIAZOL-5-YL)VINYL]-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC ACID, Penicillin-binding protein 2X, SULFATE ION Authors: Yamada, M, Watanabe, T, Takeuchi, Y. Deposit date: 2007-05-23 Release date: 2007-09-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity Antimicrob.Agents Chemother., 51, 2007
2WAD	PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204) Descriptor: PENICILLIN-BINDING PROTEIN 2B, ZINC ION Authors: Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A. Deposit date: 2009-02-05 Release date: 2009-02-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci J.Mol.Biol., 387, 2009

<12345678910111213141516>