2ZC6

Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae

Summary for 2ZC6

Entry DOI	10.2210/pdb2zc6/pdb
Related	2ZC3 2ZC4 2ZC5
Descriptor	Penicillin-binding protein 1A, ZINC ION, (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, tebipenem, antibiotic resistance, cell shape, cell wall biogenesis/degradation, multifunctional enzyme, secreted, biosynthetic protein
Biological source	Streptococcus pneumoniae More
Cellular location	Secreted: Q8DR59
Total number of polymer chains	4
Total formula weight	93706.05
Authors	Yamada, M.,Watanabe, T.,Takeuchi, Y. (deposition date: 2007-11-02, release date: 2008-04-08, Last modification date: 2023-11-01)
Primary citation	Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S. Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52:2053-2060, 2008 Cited by PubMed: 18391040 DOI: 10.1128/AAC.01456-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation