2ZC6
Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae
Summary for 2ZC6
Entry DOI | 10.2210/pdb2zc6/pdb |
Related | 2ZC3 2ZC4 2ZC5 |
Descriptor | Penicillin-binding protein 1A, ZINC ION, (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, ... (5 entities in total) |
Functional Keywords | peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, tebipenem, antibiotic resistance, cell shape, cell wall biogenesis/degradation, multifunctional enzyme, secreted, biosynthetic protein |
Biological source | Streptococcus pneumoniae More |
Cellular location | Secreted: Q8DR59 |
Total number of polymer chains | 4 |
Total formula weight | 93706.05 |
Authors | Yamada, M.,Watanabe, T.,Takeuchi, Y. (deposition date: 2007-11-02, release date: 2008-04-08, Last modification date: 2023-11-01) |
Primary citation | Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S. Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52:2053-2060, 2008 Cited by PubMed: 18391040DOI: 10.1128/AAC.01456-07 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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